Jennifer N Baldwin1, Marnee J McKay2, Claire E Hiller2, Niamh Moloney3, Elizabeth J Nightingale2, Joshua Burns4. 1. Arthritis and Musculoskeletal Research Group, Faculty of Health Sciences, University of Sydney, Australia. Electronic address: jennifer.baldwin@sydney.edu.au. 2. Arthritis and Musculoskeletal Research Group, Faculty of Health Sciences, University of Sydney, Australia. 3. Arthritis and Musculoskeletal Research Group, Faculty of Health Sciences, University of Sydney, Australia; Department of Health Sciences, Faculty of Medicine and Health Sciences, Macquarie University, Australia. 4. Arthritis and Musculoskeletal Research Group, Faculty of Health Sciences, University of Sydney, Australia; Paediatric Gait Analysis Service of New South Wales, Sydney Children's Hospitals Network (Randwick and Westmead), Australia.
Abstract
BACKGROUND: Functional outcome measures in clinical trials of musculoskeletal conditions need to be meaningful to individuals. OBJECTIVES: To investigate the relationship between physical performance and self/proxy-reported function in 1000 healthy children and adults. DESIGN: Cross-sectional observational study (1000 Norms Project). METHODS: One thousand males and females aged 3-101 years, healthy by self-report and without major physical disability, were recruited. Twelve performance-based tests were analysed: vertical and long jump, two hand dexterity tests, four balance tests, stepping reaction time, 30-second chair stand, timed up-and-down stairs, and six-minute walk. Self/proxy-reported function was assessed using the Infant-Toddler Quality of Life questionnaire, Child Health Questionnaire, Assessment of Quality of Life (AQoL)-6D Adolescent, AQoL-8D, International Physical Activity Questionnaire and work ability question. Bivariate and multivariate correlational analyses were constructed for infants (3-4y), children (5-10y), adolescents (11-17y), adults (18-59y) and older adults (60+). RESULTS/ FINDINGS: Socio-demographic characteristics were similar to the Australian population. Among infants/children, greater jump and sit-to-stand performance correlated with higher proxy-reported function (p < 0.05). There were no significant relationships observed for adolescents (p > 0.05). Greater jump, dexterity, balance, reaction time, sit-to-stand, stair-climbing and six-minute walk performance correlated with higher self-reported function in adults (r = -0.097 to.231; p < 0.05) and older adults (r = -0.135 to 0.625; p < 0.05). Multivariate regression modelling revealed a collection of independent performance measures explaining up to 46% of the variance in self/proxy-reported function. CONCLUSIONS: Many performance-based tests were significantly associated with self/proxy-reported function. We have identified a set of physical measures which could form the basis of age-appropriate functional scales for clinical trials of musculoskeletal conditions.
BACKGROUND: Functional outcome measures in clinical trials of musculoskeletal conditions need to be meaningful to individuals. OBJECTIVES: To investigate the relationship between physical performance and self/proxy-reported function in 1000 healthy children and adults. DESIGN: Cross-sectional observational study (1000 Norms Project). METHODS: One thousand males and females aged 3-101 years, healthy by self-report and without major physical disability, were recruited. Twelve performance-based tests were analysed: vertical and long jump, two hand dexterity tests, four balance tests, stepping reaction time, 30-second chair stand, timed up-and-down stairs, and six-minute walk. Self/proxy-reported function was assessed using the Infant-Toddler Quality of Life questionnaire, Child Health Questionnaire, Assessment of Quality of Life (AQoL)-6D Adolescent, AQoL-8D, International Physical Activity Questionnaire and work ability question. Bivariate and multivariate correlational analyses were constructed for infants (3-4y), children (5-10y), adolescents (11-17y), adults (18-59y) and older adults (60+). RESULTS/ FINDINGS: Socio-demographic characteristics were similar to the Australian population. Among infants/children, greater jump and sit-to-stand performance correlated with higher proxy-reported function (p < 0.05). There were no significant relationships observed for adolescents (p > 0.05). Greater jump, dexterity, balance, reaction time, sit-to-stand, stair-climbing and six-minute walk performance correlated with higher self-reported function in adults (r = -0.097 to.231; p < 0.05) and older adults (r = -0.135 to 0.625; p < 0.05). Multivariate regression modelling revealed a collection of independent performance measures explaining up to 46% of the variance in self/proxy-reported function. CONCLUSIONS: Many performance-based tests were significantly associated with self/proxy-reported function. We have identified a set of physical measures which could form the basis of age-appropriate functional scales for clinical trials of musculoskeletal conditions.
Authors: Tamara Del Corral; Javier Tapia-Castañeda; Gonzalo Ríos-Pérez; Paula Triviño-López; Nerea Sastre-Moreno; Pablo García Fernández; Ibai López-de-Uralde-Villanueva Journal: Eur J Appl Physiol Date: 2022-01-19 Impact factor: 3.078
Authors: Emily Knox; Cris Glazebrook; Tabitha Randell; Paul Leighton; Boliang Guo; James Greening; E Bethan Davies; Lori Amor; Holly Blake Journal: BMC Public Health Date: 2019-04-03 Impact factor: 3.295