Literature DB >> 28494190

Formate-nitrite transporters: Monoacids ride the dielectric slide.

Marie Wiechert1, Eric Beitz1.   

Abstract

Keywords:  dielectric environment; formate-nitrite transporter; lactate; neutralization; proton transfer; transport mechanism

Mesh：

Substances：

Year:  2017        PMID： 28494190      PMCID： PMC5626355          DOI： 10.1080/19336950.2017.1329999

Source DB:  PubMed          Journal:  Channels (Austin)        ISSN： 1933-6950            Impact factor:   2.581


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  8 in total

1.  Mechanism of ammonia transport by Amt/MEP/Rh: structure of AmtB at 1.35 A.

Authors:  Shahram Khademi; Joseph O'Connell; Jonathan Remis; Yaneth Robles-Colmenares; Larry J W Miercke; Robert M Stroud
Journal:  Science       Date:  2004-09-10       Impact factor: 47.728

2.  Identity of a Plasmodium lactate/H(+) symporter structurally unrelated to human transporters.

Authors:  Binghua Wu; Janis Rambow; Sinja Bock; Julia Holm-Bertelsen; Marie Wiechert; Alexandra Blancke Soares; Tobias Spielmann; Eric Beitz
Journal:  Nat Commun       Date:  2015-02-11       Impact factor: 14.919

3.  A lactate and formate transporter in the intraerythrocytic malaria parasite, Plasmodium falciparum.

Authors:  Rosa V Marchetti; Adele M Lehane; Sarah H Shafik; Markus Winterberg; Rowena E Martin; Kiaran Kirk
Journal:  Nat Commun       Date:  2015-03-31       Impact factor: 14.919

4.  Mechanism of formate-nitrite transporters by dielectric shift of substrate acidity.

Authors:  Marie Wiechert; Eric Beitz
Journal:  EMBO J       Date:  2017-03-01       Impact factor: 11.598

Review 5.  The formate/nitrite transporter family of anion channels.

Authors:  Wei Lü; Juan Du; Nikola J Schwarzer; Tobias Wacker; Susana L A Andrade; Oliver Einsle
Journal:  Biol Chem       Date:  2013-06       Impact factor: 3.915

6.  Isolation and characterization of hypophosphite--resistant mutants of Escherichia coli: identification of the FocA protein, encoded by the pfl operon, as a putative formate transporter.

Authors:  B Suppmann; G Sawers
Journal:  Mol Microbiol       Date:  1994-03       Impact factor: 3.501

7.  The Malaria Parasite's Lactate Transporter PfFNT Is the Target of Antiplasmodial Compounds Identified in Whole Cell Phenotypic Screens.

Authors:  Sanduni V Hapuarachchi; Simon A Cobbold; Sarah H Shafik; Adelaide S M Dennis; Malcolm J McConville; Rowena E Martin; Kiaran Kirk; Adele M Lehane
Journal:  PLoS Pathog       Date:  2017-02-08       Impact factor: 6.823

8.  Substrate-analogous inhibitors exert antimalarial action by targeting the Plasmodium lactate transporter PfFNT at nanomolar scale.

Authors:  André Golldack; Björn Henke; Bärbel Bergmann; Marie Wiechert; Holger Erler; Alexandra Blancke Soares; Tobias Spielmann; Eric Beitz
Journal:  PLoS Pathog       Date:  2017-02-08       Impact factor: 6.823
  8 in total
  4 in total

1.  The intracellular parasite Toxoplasma gondii harbors three druggable FNT-type formate and l-lactate transporters in the plasma membrane.

Authors:  Holger Erler; Bingjian Ren; Nishith Gupta; Eric Beitz
Journal:  J Biol Chem       Date:  2018-09-20       Impact factor: 5.157

2.  Formate-nitrite transporters carrying nonprotonatable amide amino acids instead of a central histidine maintain pH-dependent transport.

Authors:  Folknand Helmstetter; Philipp Arnold; Bastian Höger; Lea Madlen Petersen; Eric Beitz
Journal:  J Biol Chem       Date:  2018-11-19       Impact factor: 5.157

3.  Transmembrane Facilitation of Lactate/H+ Instead of Lactic Acid Is Not a Question of Semantics but of Cell Viability.

Authors:  Annika Bader; Eric Beitz
Journal:  Membranes (Basel)       Date:  2020-09-15

4.  Pentafluoro-3-hydroxy-pent-2-en-1-ones Potently Inhibit FNT-Type Lactate Transporters from all Five Human-Pathogenic Plasmodium Species.

Authors:  Philipp Walloch; Christian Hansen; Till Priegann; Dennis Schade; Eric Beitz
Journal:  ChemMedChem       Date:  2021-02-01       Impact factor: 3.466
  4 in total

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