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Literature DB >> 2849389

The DNA-binding properties of immediate-early and early proteins of murine cytomegalovirus.

Abstract

The DNA-binding properties of the immediate early (IE) and early proteins induced by the murine cytomegalovirus (Smith strain) in permissively infected 3T3-L 1 cells and nonpermissively infected J774A.1 cells were characterized. Eight of 10 IE proteins and 4 of 7 early proteins had affinity for DNA (native or denatured). A 96K IE protein was observed to have affinity for denatured DNA-cellulose when synthesized in J774A.1 cells but not when synthesized 3T3-L 1 cells.

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Year: 1988 PMID： 2849389 DOI： 10.1007/bf01310828

Source DB: PubMed Journal: Arch Virol ISSN： 0304-8608 Impact factor: 2.574

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References

21 in total

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The DNA-binding properties of immediate-early and early proteins of murine cytomegalovirus.

Review 1. The murine cytomegalovirus as a model for the study of viral pathogenesis and persistent infections.

2. A cytomegalovirus protein with properties of herpes simplex virus ICP8: partial purification of the polypeptide and map position of the gene.

3. Characterization of the major immediate-early polypeptides encoded by murine cytomegalovirus.

4. Herpes simplex virus immediate early infected-cell polypeptide 4 binds to DNA and promotes transcription.

5. Characterization of cytomegalovirus immediate-early genes. I. Nonpermissive rodent cells overproduce the IE94K protein form CMV (Colburn).

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