Jae-Won Hyun1, So-Young Huh2, Woojun Kim3, Min Su Park4, Suk-Won Ahn5, Joong-Yang Cho6, Byung-Jo Kim7, Sang-Hyun Lee8, Su-Hyun Kim1, Ho Jin Kim1. 1. Department of Neurology, Research Institute and Hospital of National Cancer Center, Goyang, Korea. 2. Department of Neurology, College of Medicine, Kosin University, Busan, Korea. 3. Department of Neurology, The Catholic University of Korea, Seoul, Korea. 4. Department of Neurology, College of Medicine, Yeungnam University, Daegu, Korea. 5. Department of Neurology, Chung-Ang University Hospital, Chung-Ang University College of Medicine, Seoul, Korea. 6. Department of Neurology, Ilsan Paik Hospital, Inje University College of Medicine, Goyang, Korea. 7. Department of Neurology, Korea University Medical Center, Seoul, Korea. 8. Department of Radiology, Research Institute and Hospital of National Cancer Center, Goyang, Korea.
Abstract
OBJECTIVES: We compared validity of 2010 McDonald and newly proposed 2016 Magnetic Resonance Imaging in Multiple Sclerosis (MAGNIMS) criteria for dissemination in space (DIS) in predicting the conversion to clinically definite multiple sclerosis (CDMS) in patients with clinically isolated syndrome (CIS). METHODS: Between 2006 and 2016, we enrolled 170 patients who had a first clinical event suggestive of multiple sclerosis (MS) from seven referral hospitals in Korea. Patients were classified into two groups based on the main outcome at the last follow-up: CDMS converters, who experienced a second attack, and non-converters. RESULTS: Of 170 patients with mean follow-up duration of 54 months, 51% converted to CDMS. The sensitivity, specificity, accuracy, and positive and negative predictive values of 2010 McDonald criteria were 70.9%, 63.1%, 67.1%, 66.3%, and 67.9%, and those for 2016 MAGNIMS criteria were 88.4%, 46.4%, 67.7%, 62.8%, and 79.6%, respectively. When we excluded 80 patients who underwent disease-modifying therapy before the second clinical event, the specificity increased to 92.3% and 84.6%, but the sensitivity decreased to 58.8% and 82.4% for 2010 McDonald and 2016 MAGNIMS criteria, respectively. CONCLUSION: 2016 MAGNIMS magnetic resonance imaging (MRI) criteria for DIS showed higher sensitivity but lower specificity than 2010 McDonald criteria in predicting conversion to CDMS in CIS patients.
OBJECTIVES: We compared validity of 2010 McDonald and newly proposed 2016 Magnetic Resonance Imaging in Multiple Sclerosis (MAGNIMS) criteria for dissemination in space (DIS) in predicting the conversion to clinically definite multiple sclerosis (CDMS) in patients with clinically isolated syndrome (CIS). METHODS: Between 2006 and 2016, we enrolled 170 patients who had a first clinical event suggestive of multiple sclerosis (MS) from seven referral hospitals in Korea. Patients were classified into two groups based on the main outcome at the last follow-up: CDMS converters, who experienced a second attack, and non-converters. RESULTS: Of 170 patients with mean follow-up duration of 54 months, 51% converted to CDMS. The sensitivity, specificity, accuracy, and positive and negative predictive values of 2010 McDonald criteria were 70.9%, 63.1%, 67.1%, 66.3%, and 67.9%, and those for 2016 MAGNIMS criteria were 88.4%, 46.4%, 67.7%, 62.8%, and 79.6%, respectively. When we excluded 80 patients who underwent disease-modifying therapy before the second clinical event, the specificity increased to 92.3% and 84.6%, but the sensitivity decreased to 58.8% and 82.4% for 2010 McDonald and 2016 MAGNIMS criteria, respectively. CONCLUSION: 2016 MAGNIMS magnetic resonance imaging (MRI) criteria for DIS showed higher sensitivity but lower specificity than 2010 McDonald criteria in predicting conversion to CDMS in CIS patients.
Authors: Omar Al-Louzi; Sargis Manukyan; Maxime Donadieu; Martina Absinta; Vijay Letchuman; Brent Calabresi; Parth Desai; Erin S Beck; Snehashis Roy; Joan Ohayon; Dzung L Pham; Anish Thomas; Steven Jacobson; Irene Cortese; Pavan K Auluck; Govind Nair; Pascal Sati; Daniel S Reich Journal: Mult Scler Date: 2022-06-08 Impact factor: 5.855