| Literature DB >> 28492076 |
Thibaud Mabit1, Aymeric Siard1, Mathilde Pantin1, Doumadé Zon1, Laura Foulgoc1, Drissa Sissouma1, André Guingant1, Monique Mathé-Allainmat1, Jacques Lebreton1, François Carreaux2, Gilles Dujardin3, Sylvain Collet1.
Abstract
An efficient access for the synthesis of pluramycinones is described. Total syntheses of racemic γ-indomycinone and kidamycinone were achieved by means of two Diels-Alder reactions. A first Diels-Alder condensation followed by a Stille cross-coupling is used for the elaboration of the desired substituted dienes which will be involved in the second pericyclic reaction with juglone to construct the tetracyclic core of pluramycinones.Entities:
Year: 2017 PMID： 28492076 DOI： 10.1021/acs.joc.7b00544
Source DB: PubMed Journal: J Org Chem ISSN： 0022-3263 Impact factor: 4.354