Hasmot Ali1,2, Jena Hamadani3, Sucheta Mehra2, Fahmida Tofail3, Md Imrul Hasan3, Saijuddin Shaikh4,2, Abu Ahmed Shamim5, Lee S-F Wu2, Keith P West2, Parul Christian2,6. 1. The JiVitA Project, Johns Hopkins University Bangladesh, Paschim Para, Gaibandha, Bangladesh; hasmot.jivita@gmail.com. 2. Center for Human Nutrition, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD. 3. Child Development Unit, International Center for Diarrheal Disease Research, Bangladesh, Dhaka, Bangladesh. 4. The JiVitA Project, Johns Hopkins University Bangladesh, Paschim Para, Gaibandha, Bangladesh. 5. FHI 360, Dhaka, Bangladesh; and. 6. Bill & Melinda Gates Foundation, Seattle, WA.
Abstract
Background: The impact of early vitamin A supplementation on neurodevelopmental function has not been adequately studied. In rural Bangladesh we examined cognitive and motor function and scholastic achievement in a cohort of children who were exposed to vitamin A in utero or at birth.Objective: The aim of this study was to examine independent and combined effects of antenatal and newborn supplementation with vitamin A on the cognitive function of children at 8 y of age.Design: A cohort of rural Bangladeshi children from 2 previous double-blind, placebo-controlled cluster-randomized trials were revisited at age 8 y between February 2013 and June 2014. Data on sociodemographic, social, and physical conditions; schooling; child care behavior; anthropometric measures; and cognitive function were collected with the use of various psychometric assessment tools. Results: Among 11,950 children from the parent trial who were last known to be alive, a subset of 1803 children balanced by treatment group in a selected contiguous study area were re-enrolled and 1613 (89%) provided consent for assessments. Of these, 1577 (87%) children had a complete cognitive evaluation. All groups were highly comparable on baseline variables collected in the previous trials and factors measured at re-enrollment. Overall, there was no impact of either maternal or newborn supplementation with vitamin A on intelligence, memory, and motor function. Compared with placebo, children who received both interventions had significantly better performance in reading, spelling, and math computation, with increased mean (95% CI) scores of 8.0 (2.2, 13.8), 6.8 (1.9, 11.7), and 4.8 (0.6, 9.0), respectively.Conclusions: General intelligence or memory and motor functions were not affected by antenatal or newborn supplementation with vitamin A. Scholastic performance and aspects of executive function improved when both interventions were provided. These trials were registered at clinicaltrials.gov as NCT00198822 and NCT00128557.
RCT Entities:
Background: The impact of early vitamin A supplementation on neurodevelopmental function has not been adequately studied. In rural Bangladesh we examined cognitive and motor function and scholastic achievement in a cohort of children who were exposed to vitamin A in utero or at birth.Objective: The aim of this study was to examine independent and combined effects of antenatal and newborn supplementation with vitamin A on the cognitive function of children at 8 y of age.Design: A cohort of rural Bangladeshi children from 2 previous double-blind, placebo-controlled cluster-randomized trials were revisited at age 8 y between February 2013 and June 2014. Data on sociodemographic, social, and physical conditions; schooling; child care behavior; anthropometric measures; and cognitive function were collected with the use of various psychometric assessment tools. Results: Among 11,950 children from the parent trial who were last known to be alive, a subset of 1803 children balanced by treatment group in a selected contiguous study area were re-enrolled and 1613 (89%) provided consent for assessments. Of these, 1577 (87%) children had a complete cognitive evaluation. All groups were highly comparable on baseline variables collected in the previous trials and factors measured at re-enrollment. Overall, there was no impact of either maternal or newborn supplementation with vitamin A on intelligence, memory, and motor function. Compared with placebo, children who received both interventions had significantly better performance in reading, spelling, and math computation, with increased mean (95% CI) scores of 8.0 (2.2, 13.8), 6.8 (1.9, 11.7), and 4.8 (0.6, 9.0), respectively.Conclusions: General intelligence or memory and motor functions were not affected by antenatal or newborn supplementation with vitamin A. Scholastic performance and aspects of executive function improved when both interventions were provided. These trials were registered at clinicaltrials.gov as NCT00198822 and NCT00128557.
Authors: Helen O Pitchik; Wafaie W Fawzi; Dana Charles McCoy; Anne Marie Darling; Ajibola I Abioye; Florence Tesha; Emily R Smith; Ferdinand Mugusi; Christopher R Sudfeld Journal: Child Care Health Dev Date: 2018-08-19 Impact factor: 2.508
Authors: Andrew L Thorne-Lyman; Saijuddin Shaikh; Sucheta Mehra; Lee S F Wu; Hasmot Ali; Kelsey Alland; Kerry J Schultze; Maithilee Mitra; Jinhee Hur; Parul Christian; Alain B Labrique; Keith P West Journal: Ann N Y Acad Sci Date: 2019-08-12 Impact factor: 5.691
Authors: Birit F P Broekman; Mary F F Chong; Jun S Lai; Shirong Cai; Bee Lan Lee; Keith M Godfrey; Peter D Gluckman; Lynette P Shek; Fabian Yap; Kok Hian Tan; Yap Seng Chong; Choon Nam Ong; Michael J Meaney; Anne Rifkin-Graboi Journal: Eur J Nutr Date: 2020-05-20 Impact factor: 5.614