Literature DB >> 28490014

Aryl Hydrocarbon Receptor Activation in Chronic Kidney Disease: Role of Uremic Toxins.

Jessyca S Brito1, Natália A Borges, Marta Esgalhado, D''Angelo C Magliano, Christophe O Soulage, Denise Mafra.   

Abstract

The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor involved in the expression of xenobiotic-metabolizing enzymes, inflammatory cytokines and adhesion molecules. Uremic toxins such as indoxyl sulfate and indole acetic acid are derived from tryptophan fermentation by gut microbiota; they accumulate in patients with chronic kidney disease (CKD) on haemodialysis and have recently emerged as potent ligands of AhR. Therefore, AhR can serve as a mediator in inflammation and cardiovascular diseases in these patients. This review discusses current data that support a link between AhR activation and uremic toxins from gut microbiota in CKD.
© 2017 S. Karger AG, Basel.

Entities:  

Keywords:  Aryl hydrocarbon receptor; Chronic kidney disease; Inflammation; Uremic toxins

Mesh：

Substances：

Year:  2017        PMID： 28490014     DOI： 10.1159/000476074

Source DB:  PubMed          Journal:  Nephron        ISSN： 1660-8151            Impact factor:   2.847


  23 in total

1.  Jian-Pi-Yi-Shen Formula Improves Adenine-Induced Chronic Kidney Disease via Regulating Tryptophan Metabolism and Aryl Hydrocarbon Receptor Signaling.

Authors:  Xinhui Liu; Ruyu Deng; Yulian Chen; Shiying Huang; Jiandong Lu; Lin Zheng; Guoliang Xiong; Shunmin Li
Journal:  Front Pharmacol       Date:  2022-07-05       Impact factor: 5.988

2.  An aryl hydrocarbon receptor agonist suppresses the growth of human umbilical vein endothelial cells in vitro: Potent effect with polyunsaturated fatty acids.

Authors:  Masayoshi Yamaguchi; Oliver Hankinson
Journal:  Int J Exp Pathol       Date:  2020-09-28       Impact factor: 1.925

Review 3.  Deleting Death and Dialysis: Conservative Care of Cardio-Vascular Risk and Kidney Function Loss in Chronic Kidney Disease (CKD).

Authors:  Raymond Vanholder; Steven Van Laecke; Griet Glorieux; Francis Verbeke; Esmeralda Castillo-Rodriguez; Alberto Ortiz
Journal:  Toxins (Basel)       Date:  2018-06-12       Impact factor: 4.546

4.  Identification of endogenous 1-aminopyrene as a novel mediator of progressive chronic kidney disease via aryl hydrocarbon receptor activation.

Authors:  Hua Miao; Gang Cao; Xia-Qing Wu; Yuan-Yuan Chen; Dan-Qian Chen; Lin Chen; Nosratola D Vaziri; Ya-Long Feng; Wei Su; Yi Gao; Shougang Zhuang; Xiao-Yong Yu; Li Zhang; Yan Guo; Ying-Yong Zhao
Journal:  Br J Pharmacol       Date:  2020-05-28       Impact factor: 8.739

5.  Indoxyl sulfate impairs angiogenesis via chronic aryl hydrocarbon receptor activation.

Authors:  Zachary R Salyers; Madeline Coleman; Nicholas P Balestrieri; Terence E Ryan
Journal:  Am J Physiol Cell Physiol       Date:  2021-01-06       Impact factor: 4.249

6.  2,3,7,8‑Tetrachlorodibenzo‑p‑dioxin suppresses the growth of human liver cancer HepG2 cells in vitro: Involvement of cell signaling factors.

Authors:  Masayoshi Yamaguchi; Oliver Hankinson
Journal:  Int J Oncol       Date:  2018-07-27       Impact factor: 5.650

7.  2,3,7,8‑tetrachlorodibenzo‑p‑dioxin suppresses the growth of human colorectal cancer cells in vitro: Implication of the aryl hydrocarbon receptor signaling.

Authors:  Masayoshi Yamaguchi; Oliver Hankinson
Journal:  Int J Oncol       Date:  2019-01-30       Impact factor: 5.650

Review 8.  Aryl hydrocarbon receptor activation mediates kidney disease and renal cell carcinoma.

Authors:  Hui Zhao; Lin Chen; Tian Yang; Ya-Long Feng; Nosratola D Vaziri; Bao-Li Liu; Qing-Quan Liu; Yan Guo; Ying-Yong Zhao
Journal:  J Transl Med       Date:  2019-09-05       Impact factor: 5.531

9.  Uremic toxins levels from the gut microbiota seem not to be altered by physical exercise in hemodialysis patients.

Authors:  Jessyca Sousa de Brito; Drielly Vargas; Greicielle Santos da Silva; Sandra Marinho; Natália Alvarenga Borges; Ludmila F M F Cardozo; Larissa Fonseca; Marcia Ribeiro; Tuany Ramos Chermut; Mariana Moura; Bruna Regis; Tassiana Meireles; Lia S Nakao; Denise Mafra
Journal:  Int Urol Nephrol       Date:  2021-07-12       Impact factor: 2.370

10.  Towards an Integrative Understanding of tRNA Aminoacylation-Diet-Host-Gut Microbiome Interactions in Neurodegeneration.

Authors:  Elena L Paley; George Perry
Journal:  Nutrients       Date:  2018-03-26       Impact factor: 5.717
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