Literature DB >> 28489961

The role of Exo70 in exocytosis and beyond.

Yueyao Zhu1, Bin Wu1, Wei Guo1.   

Abstract

The exocyst complex mediates the tethering of secretory vesicles to the plasma membrane before SNARE-mediated membrane fusion. Recent studies have implicated the exocyst in a wide range of cellular processes. Particularly, research on the Exo70 subunit of the complex has linked the function of the exocyst in exocytosis to cell adhesion, migration and invasion. In this review, we will discuss the recent work on how Exo70 regulates these cellular processes, and how small GTPases and kinases interact with Exo70 to orchestrate its function in exocytosis and cytoskeleton organization. The study of Exo70 contributes to the understanding of many pathophysiological processes from organogenesis to cancer metastasis.

Entities:  

Keywords:  Exo70; cell adhesion; cell invasion; cell migration; exocyst; invadopodia; lamellipodia

Mesh：

Substances：

Year:  2017        PMID： 28489961      PMCID： PMC6748379          DOI： 10.1080/21541248.2017.1328998

Source DB:  PubMed          Journal:  Small GTPases        ISSN： 2154-1248


  33 in total

1.  Exocyst requirement for endocytic traffic directed toward the apical and basolateral poles of polarized MDCK cells.

Authors:  Asli Oztan; Mark Silvis; Ora A Weisz; Neil A Bradbury; Shu-Chan Hsu; James R Goldenring; Charles Yeaman; Gerard Apodaca
Journal:  Mol Biol Cell       Date:  2007-08-08       Impact factor: 4.138

Review 2.  Steering cell migration: lamellipodium dynamics and the regulation of directional persistence.

Authors:  Matthias Krause; Alexis Gautreau
Journal:  Nat Rev Mol Cell Biol       Date:  2014-09       Impact factor: 94.444

3.  Exo70 interacts with the Arp2/3 complex and regulates cell migration.

Authors:  Xiaofeng Zuo; Jian Zhang; Ying Zhang; Shu-Chan Hsu; Daoguo Zhou; Wei Guo
Journal:  Nat Cell Biol       Date:  2006-11-05       Impact factor: 28.824

4.  Sec3-containing exocyst complex is required for desmosome assembly in mammalian epithelial cells.

Authors:  Nicholas J Andersen; Charles Yeaman
Journal:  Mol Biol Cell       Date:  2009-11-04       Impact factor: 4.138

5.  Ral-regulated interaction between Sec5 and paxillin targets Exocyst to focal complexes during cell migration.

Authors:  Krystle S Spiczka; Charles Yeaman
Journal:  J Cell Sci       Date:  2008-08-12       Impact factor: 5.285

6.  The role of the exocyst in matrix metalloproteinase secretion and actin dynamics during tumor cell invadopodia formation.

Authors:  Jianglan Liu; Peng Yue; Vira V Artym; Susette C Mueller; Wei Guo
Journal:  Mol Biol Cell       Date:  2009-06-17       Impact factor: 4.138

7.  Dynamic interactions of cortactin and membrane type 1 matrix metalloproteinase at invadopodia: defining the stages of invadopodia formation and function.

Authors:  Vira V Artym; Ying Zhang; Françoise Seillier-Moiseiwitsch; Kenneth M Yamada; Susette C Mueller
Journal:  Cancer Res       Date:  2006-03-15       Impact factor: 12.701

8.  Sec6/8 complex is recruited to cell-cell contacts and specifies transport vesicle delivery to the basal-lateral membrane in epithelial cells.

Authors:  K K Grindstaff; C Yeaman; N Anandasabapathy; S C Hsu; E Rodriguez-Boulan; R H Scheller; W J Nelson
Journal:  Cell       Date:  1998-05-29       Impact factor: 41.582

9.  Exo70 generates membrane curvature for morphogenesis and cell migration.

Authors:  Yuting Zhao; Jianglan Liu; Changsong Yang; Benjamin R Capraro; Tobias Baumgart; Ryan P Bradley; N Ramakrishnan; Xiaowei Xu; Ravi Radhakrishnan; Tatyana Svitkina; Wei Guo
Journal:  Dev Cell       Date:  2013-08-12       Impact factor: 12.270

10.  Yeast Cdc42 functions at a late step in exocytosis, specifically during polarized growth of the emerging bud.

Authors:  J E Adamo; J J Moskow; A S Gladfelter; D Viterbo; D J Lew; P J Brennwald
Journal:  J Cell Biol       Date:  2001-11-12       Impact factor: 10.539
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  5 in total

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Authors:  FuiBoon Kai; Guanqing Ou; Richard W Tourdot; Connor Stashko; Guido Gaietta; Mark F Swift; Niels Volkmann; Alexandra F Long; Yulong Han; Hector H Huang; Jason J Northey; Andrew M Leidal; Virgile Viasnoff; David M Bryant; Wei Guo; Arun P Wiita; Ming Guo; Sophie Dumont; Dorit Hanein; Ravi Radhakrishnan; Valerie M Weaver
Journal:  EMBO J       Date:  2022-07-25       Impact factor: 14.012

2.  The Upregulated Expression of the Citrus RIN4 Gene in HLB Diseased Citrus Aids Candidatus Liberibacter Asiaticus Infection.

Authors:  Chunzhen Cheng; Yun Zhong; Bin Wang; Yongyan Zhang; Huan Wu; Nonghui Jiang; Bo Wu; Yuanda Lv; Bo Jiang
Journal:  Int J Mol Sci       Date:  2022-06-23       Impact factor: 6.208

3.  A fine balance between Prpf19 and Exoc7 in achieving degradation of aggregated protein and suppression of cell death in spinocerebellar ataxia type 3.

Authors:  Zhefan Stephen Chen; Xiaoying Huang; Kevin Talbot; Ho Yin Edwin Chan
Journal:  Cell Death Dis       Date:  2021-02-02       Impact factor: 8.469

4.  Genome-wide identification and expression analysis of the EXO70 gene family in grape (Vitis vinifera L).

Authors:  Han Wang; Zong-Huan Ma; Juan Mao; Bai-Hong Chen
Journal:  PeerJ       Date:  2021-04-21       Impact factor: 2.984

5.  B Cells Adapt Their Nuclear Morphology to Organize the Immune Synapse and Facilitate Antigen Extraction.

Authors:  Romina Ulloa; Oreste Corrales; Fernanda Cabrera-Reyes; Jorge Jara-Wilde; Juan José Saez; Christopher Rivas; Jonathan Lagos; Steffen Härtel; Clara Quiroga; María-Isabel Yuseff; Jheimmy Diaz-Muñoz
Journal:  Front Immunol       Date:  2022-02-09       Impact factor: 7.561
  5 in total

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