BACKGROUND: Only 13% of HIV-positive young adults are estimated to be virally suppressed and, even among those receiving medical care, HIV-positive young adults are less likely than older adults to take antiretroviral therapy (ART), be adherent, and be virally suppressed. We sought to examine trends in treatment and health outcomes from 2009 to 2013 among HIV-positive young adults (aged 18-24 years) in care. SETTING: The Medical Monitoring Project is a complex sample survey of HIV-infected adults receiving medical care in the United States. METHODS: We used weighted interview and medical record data collected from June 2009 to May 2014 to estimate trends in the prevalence of ART prescription, adherence, side effects, single-tablet ART regimens, regular care utilization, and viral suppression among young adults. RESULTS: From 2009 to 2013, there were significant increases in ART prescription (76%-87%) and the proportion of young adults taking ART who reported taking single-tablet regimens (49%-62%). There was no significant change in adherence, side effects, or regular care utilization. Although viral suppression at last test did not change (65% at both time periods), the proportion of young adults who were sustainably virally suppressed significantly increased (29%-46%). Accounting for ART prescription and single-tablet regimen use attenuated the sustained viral suppression trend. CONCLUSIONS: Although the level of viral suppression among young adults in care remains suboptimal, the observed increases in ART prescription and sustained viral suppression may be a cause for optimism regarding efforts to improve outcomes for this vulnerable population.
BACKGROUND: Only 13% of HIV-positive young adults are estimated to be virally suppressed and, even among those receiving medical care, HIV-positive young adults are less likely than older adults to take antiretroviral therapy (ART), be adherent, and be virally suppressed. We sought to examine trends in treatment and health outcomes from 2009 to 2013 among HIV-positive young adults (aged 18-24 years) in care. SETTING: The Medical Monitoring Project is a complex sample survey of HIV-infected adults receiving medical care in the United States. METHODS: We used weighted interview and medical record data collected from June 2009 to May 2014 to estimate trends in the prevalence of ART prescription, adherence, side effects, single-tablet ART regimens, regular care utilization, and viral suppression among young adults. RESULTS: From 2009 to 2013, there were significant increases in ART prescription (76%-87%) and the proportion of young adults taking ART who reported taking single-tablet regimens (49%-62%). There was no significant change in adherence, side effects, or regular care utilization. Although viral suppression at last test did not change (65% at both time periods), the proportion of young adults who were sustainably virally suppressed significantly increased (29%-46%). Accounting for ART prescription and single-tablet regimen use attenuated the sustained viral suppression trend. CONCLUSIONS: Although the level of viral suppression among young adults in care remains suboptimal, the observed increases in ART prescription and sustained viral suppression may be a cause for optimism regarding efforts to improve outcomes for this vulnerable population.
Authors: Shoshana Y Kahana; Maria Isabel Fernandez; Patrick A Wilson; Jose A Bauermeister; Sonia Lee; Craig M Wilson; Lisa B Hightow-Weidman Journal: J Acquir Immune Defic Syndr Date: 2015-02-01 Impact factor: 3.731
Authors: Janet M Blair; Jennifer L Fagan; Emma L Frazier; Ann Do; Heather Bradley; Eduardo E Valverde; Ad McNaghten; Linda Beer; Shuyan Zhang; Ping Huang; Christine L Mattson; Mark S Freedman; Christopher H Johnson; Catherine C Sanders; Kathryn E Spruit-McGoff; James D Heffelfinger; Jacek Skarbinski Journal: MMWR Suppl Date: 2014-06-20
Authors: Heather Bradley; H Irene Hall; Richard J Wolitski; Michelle M Van Handel; Amy E Stone; Michael LaFlam; Jacek Skarbinski; Darrel H Higa; Joseph Prejean; Emma L Frazier; Roshni Patel; Ping Huang; Qian An; Ruiguang Song; Tian Tang; Linda A Valleroy Journal: MMWR Morb Mortal Wkly Rep Date: 2014-11-28 Impact factor: 17.586
Authors: Margaret T May; Mark Gompels; Valerie Delpech; Kholoud Porter; Chloe Orkin; Stephen Kegg; Phillip Hay; Margaret Johnson; Adrian Palfreeman; Richard Gilson; David Chadwick; Fabiola Martin; Teresa Hill; John Walsh; Frank Post; Martin Fisher; Jonathan Ainsworth; Sophie Jose; Clifford Leen; Mark Nelson; Jane Anderson; Caroline Sabin Journal: AIDS Date: 2014-05-15 Impact factor: 4.177
Authors: Kevin M Maloney; Adrien Le Guillou; Robert A Driggers; Supriya Sarkar; Emeli J Anderson; Amyn A Malik; Samuel M Jenness Journal: J Infect Dis Date: 2021-01-04 Impact factor: 5.226
Authors: Samuel M Jenness; Kevin M Maloney; Dawn K Smith; Karen W Hoover; Steven M Goodreau; Eli S Rosenberg; Kevin M Weiss; Albert Y Liu; Darcy W Rao; Patrick S Sullivan Journal: Am J Epidemiol Date: 2019-04-01 Impact factor: 4.897
Authors: Katie B Biello; Casey Horvitz; Shelby Mullin; Kenneth H Mayer; Hyman Scott; Kenneth Coleman; Julian Dormitzer; Jenna Norelli; Lisa Hightow-Weidman; Patrick Sullivan; Matthew J Mimiaga; Susan Buchbinder; Kelly Bojan; Donna Futterman; Patricia Emmanuel; Albert Liu Journal: Mhealth Date: 2021-04-20
Authors: Putu Duff; Kate Shannon; Melissa Braschel; Flo Ranville; Mary Kestler; Ruth Elwood Martin; Andrea Krüsi; Kathleen Deering Journal: Int J STD AIDS Date: 2020-12-08 Impact factor: 1.359
Authors: Annouschka M Weijsenfeld; Charlotte Blokhuis; Martijn M Stuiver; Ferdinand W N M Wit; Dasja Pajkrt Journal: Medicine (Baltimore) Date: 2019-08 Impact factor: 1.817
Authors: Kevin M Weiss; Steven M Goodreau; Martina Morris; Pragati Prasad; Ramya Ramaraju; Travis Sanchez; Samuel M Jenness Journal: Epidemics Date: 2020-01-24 Impact factor: 4.396