Literature DB >> 28489327

New directions for the treatment of depression: Targeting the photic regulation of arousal and mood (PRAM) pathway.

Hannah E Bowrey1,2, Morgan H James1,3, Gary Aston-Jones1.   

Abstract

Both preclinical and clinical studies demonstrate that depression is strongly associated with reduced light availability, which in turn contributes to decreased function of brain regions that control mood. Here, we review findings that support a critical pathway for the control of mood that depends upon ambient light. We put forward a novel hypothesis, functionally linking retina to locus coeruleus (LC) in depression, and discuss the role of norepinephrine in affective disease. Finally, we discuss how utilizing the chemogenetic tool Designer Receptors Exclusively Activated by Designer Drugs (DREADDs) to precisely control this retina-LC circuit may be used as a novel therapeutic to treat depression.
© 2017 Wiley Periodicals, Inc.

Entities:  

Keywords:  antidepressants; anxiety/anxiety disorders; depression; mood disorders; pharmacotherapy; seasonal affective disorder; sleep disorders; stress; treatment

Mesh：

Substances：

Year:  2017        PMID： 28489327      PMCID： PMC5797474          DOI： 10.1002/da.22635

Source DB:  PubMed          Journal:  Depress Anxiety        ISSN： 1091-4269            Impact factor:   6.505


  95 in total

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Authors:  J Harro; L Oreland; E Vasar; J Bradwejn
Journal:  Eur Neuropsychopharmacol       Date:  1995-12       Impact factor: 4.600

2.  Olfactory bulbectomy increases basal suprachiasmatic cyclic AMP levels in male rats.

Authors:  M E Vagell; M Y McGinnis; B P Possidente; V N Narasimhan; A R Lumia
Journal:  Brain Res Bull       Date:  1991-12       Impact factor: 4.077

Review 3.  The locus coeruleus-noradrenergic system: modulation of behavioral state and state-dependent cognitive processes.

Authors:  Craig W Berridge; Barry D Waterhouse
Journal:  Brain Res Brain Res Rev       Date:  2003-04

4.  Identifying genes in monoamine nuclei that may determine stress vulnerability and depressive behavior in Wistar-Kyoto rats.

Authors:  Kimberly A Pearson; Alisson Stephen; Sheryl G Beck; Rita J Valentino
Journal:  Neuropsychopharmacology       Date:  2006-05-17       Impact factor: 7.853

5.  Light deprivation damages monoamine neurons and produces a depressive behavioral phenotype in rats.

Authors:  M M C Gonzalez; G Aston-Jones
Journal:  Proc Natl Acad Sci U S A       Date:  2008-03-17       Impact factor: 11.205

6.  Altered expression of glutamate signaling, growth factor, and glia genes in the locus coeruleus of patients with major depression.

Authors:  R Bernard; I A Kerman; R C Thompson; E G Jones; W E Bunney; J D Barchas; A F Schatzberg; R M Myers; H Akil; S J Watson
Journal:  Mol Psychiatry       Date:  2010-04-13       Impact factor: 15.992

Review 7.  Vascular endothelial growth factor: biology and therapeutic applications.

Authors:  Quoc T Ho; Calvin J Kuo
Journal:  Int J Biochem Cell Biol       Date:  2007-04-22       Impact factor: 5.085

Review 8.  Light as a central modulator of circadian rhythms, sleep and affect.

Authors:  Tara A LeGates; Diego C Fernandez; Samer Hattar
Journal:  Nat Rev Neurosci       Date:  2014-06-11       Impact factor: 34.870

9.  Genome-wide association study of major depressive disorder: new results, meta-analysis, and lessons learned.

Authors:  N R Wray; M L Pergadia; D H R Blackwood; B W J H Penninx; S D Gordon; D R Nyholt; S Ripke; D J MacIntyre; K A McGhee; A W Maclean; J H Smit; J J Hottenga; G Willemsen; C M Middeldorp; E J C de Geus; C M Lewis; P McGuffin; I B Hickie; E J C G van den Oord; J Z Liu; S Macgregor; B P McEvoy; E M Byrne; S E Medland; D J Statham; A K Henders; A C Heath; G W Montgomery; N G Martin; D I Boomsma; P A F Madden; P F Sullivan
Journal:  Mol Psychiatry       Date:  2010-11-02       Impact factor: 15.992

10.  Genome-wide association study of recurrent early-onset major depressive disorder.

Authors:  J Shi; J B Potash; J A Knowles; M M Weissman; W Coryell; W A Scheftner; W B Lawson; J R DePaulo; P V Gejman; A R Sanders; J K Johnson; P Adams; S Chaudhury; D Jancic; O Evgrafov; A Zvinyatskovskiy; N Ertman; M Gladis; K Neimanas; M Goodell; N Hale; N Ney; R Verma; D Mirel; P Holmans; D F Levinson
Journal:  Mol Psychiatry       Date:  2010-02-02       Impact factor: 15.992
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  9 in total

1.  Chronic light exposure alters serotonergic and orexinergic systems in the rat brain and reverses maternal separation-induced increase in orexin receptors in the prefrontal cortex.

Authors:  J J Dimatelis; A Mtintsilana; V Naidoo; D J Stein; V A Russell
Journal:  Metab Brain Dis       Date:  2017-10-16       Impact factor: 3.584

Review 2.  Newly identified sleep-wake and circadian circuits as potential therapeutic targets.

Authors:  Anne Venner; William D Todd; Jimmy Fraigne; Hannah Bowrey; Ada Eban-Rothschild; Satvinder Kaur; Christelle Anaclet
Journal:  Sleep       Date:  2019-05-01       Impact factor: 5.849

3.  Magnetoencephalographic correlates of mood and reward dynamics in human adolescents.

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Journal:  Cereb Cortex       Date:  2022-07-21       Impact factor: 4.861

4.  Outdoor daylight exposure and longer sleep promote wellbeing under COVID-19 mandated restrictions.

Authors:  Maria Korman; Vadim Tkachev; Cátia Reis; Yoko Komada; Shingo Kitamura; Denis Gubin; Vinod Kumar; Till Roenneberg
Journal:  J Sleep Res       Date:  2021-09-21       Impact factor: 5.296

Review 5.  The orexin (hypocretin) neuropeptide system is a target for novel therapeutics to treat cocaine use disorder with alcohol coabuse.

Authors:  Morgan H James; Jennifer E Fragale; Shayna L O'Connor; Benjamin A Zimmer; Gary Aston-Jones
Journal:  Neuropharmacology       Date:  2020-10-19       Impact factor: 5.250

Review 6.  Orexin/hypocretin receptor modulation of anxiolytic and antidepressive responses during social stress and decision-making: Potential for therapy.

Authors:  Cliff H Summers; Jazmine D W Yaeger; Clarissa D Staton; David H Arendt; Tangi R Summers
Journal:  Brain Res       Date:  2018-12-24       Impact factor: 3.252

Review 7.  Locus coeruleus: a new look at the blue spot.

Authors:  Gina R Poe; Stephen Foote; Oxana Eschenko; Joshua P Johansen; Sebastien Bouret; Gary Aston-Jones; Carolyn W Harley; Denise Manahan-Vaughan; David Weinshenker; Rita Valentino; Craig Berridge; Daniel J Chandler; Barry Waterhouse; Susan J Sara
Journal:  Nat Rev Neurosci       Date:  2020-09-17       Impact factor: 34.870

Review 8.  Potential Pathways for Circadian Dysfunction and Sundowning-Related Behavioral Aggression in Alzheimer's Disease and Related Dementias.

Authors:  William D Todd
Journal:  Front Neurosci       Date:  2020-09-03       Impact factor: 5.152

Review 9.  The darkness and the light: diurnal rodent models for seasonal affective disorder.

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Journal:  Dis Model Mech       Date:  2021-01-26       Impact factor: 5.758
  9 in total

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