Literature DB >> 2848919

Antibody-mediated enhancement of calcium permeability in cardiac myocytes.

H P Schultheiss1, U Kühl, I Janda, B Melzner, G Ulrich, M Morad.   

Abstract

Our study shows that antibodies, specific to the ADP/ATP carrier of the inner mitochondrial membrane, crossreact with the cell surface of cardiac myocytes, where the calcium channel seems to be the antigenic determinant. The antibodies enhanced the calcium current and suppressed its inactivation. Affinity-purified antibodies (IgG) exhibit an acute cytotoxic effect, which required extracellular calcium and was prevented by calcium channel blockers. Our findings suggest that antibody-mediated cytotoxicity results secondary to calcium overload caused by enhanced cellular calcium permeability, requiring no complement-dependent process.

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Year:  1988        PMID： 2848919      PMCID： PMC2189146          DOI： 10.1084/jem.168.6.2105

Source DB:  PubMed          Journal:  J Exp Med        ISSN： 0022-1007            Impact factor:   14.307


  18 in total

1.  Determination of serum proteins by means of the biuret reaction.

Authors:  A G GORNALL; C J BARDAWILL; M M DAVID
Journal:  J Biol Chem       Date:  1949-02       Impact factor: 5.157

2.  Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications.

Authors:  H Towbin; T Staehelin; J Gordon
Journal:  Proc Natl Acad Sci U S A       Date:  1979-09       Impact factor: 11.205

3.  Isolated calcium-tolerant myocytes and the calcium paradox: an ultrastructural comparison.

Authors:  A M Slade; N J Severs; T Powell; V W Twist
Journal:  Eur Heart J       Date:  1983-12       Impact factor: 29.983

Review 4.  Calcium movements in relation to heart function.

Authors:  N S Dhalla; G N Pierce; V Panagia; P K Singal; R E Beamish
Journal:  Basic Res Cardiol       Date:  1982 Mar-Apr       Impact factor: 17.165

5.  The mitochondrial adenine nucleotide translocator is an antigen in primary biliary cirrhosis.

Authors:  H P Schultheiss; P Berg; M Klingenberg
Journal:  Clin Exp Immunol       Date:  1983-12       Impact factor: 4.330

Review 6.  Isolated cardiac myocytes. II. Functional aspects of mature cells.

Authors:  J W Dow; N G Harding; T Powell
Journal:  Cardiovasc Res       Date:  1981-10       Impact factor: 10.787

7.  Compartmentation of K+ in isolated adult rat heart cells.

Authors:  R Altschuld; C Hohl; A Ansel; G P Brierley
Journal:  Arch Biochem Biophys       Date:  1981-06       Impact factor: 4.013

8.  Calcium tolerance of isolated rat heart cells.

Authors:  R Altschuld; L Gibb; A Ansel; C Hohl; F A Kruger; G P Brierley
Journal:  J Mol Cell Cardiol       Date:  1980-12       Impact factor: 5.000

9.  Adenine nucleotide metabolism and compartmentalization in isolated adult rat heart cells.

Authors:  T Geisbuhler; R A Altschuld; R W Trewyn; A Z Ansel; K Lamka; G P Brierley
Journal:  Circ Res       Date:  1984-05       Impact factor: 17.367

10.  Energy levels at systole vs. diastole in normal hamster hearts vs. myopathic hamster hearts.

Authors:  R Sievers; W W Parmley; T James; J Wikman-Coffelt
Journal:  Circ Res       Date:  1983-12       Impact factor: 17.367
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  25 in total

1.  Identification of a putative shared epitope between Coxsackie virus B4 and alpha cardiac myosin heavy chain.

Authors:  K W Beisel; J Srinivasappa; B S Prabhakar
Journal:  Clin Exp Immunol       Date:  1991-10       Impact factor: 4.330

2.  Foreword to special issue on "Myocarditis".

Authors:  Alida L P Caforio
Journal:  Heart Fail Rev       Date:  2013-11       Impact factor: 4.214

3.  Agonist-like autoantibodies against calcium channel in patients with dilated cardiomyopathy.

Authors:  Hua Xiao; Min Wang; Yimei Du; Jing Yuan; Guanghong Zhao; Danna Tu; Yu-Hua Liao
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4.  The significance of autoantibodies against the ADP/ATP carrier for the pathogenesis of myocarditis and dilated cardiomyopathy--clinical and experimental data.

Authors:  H P Schultheiss
Journal:  Springer Semin Immunopathol       Date:  1989

5.  Lessons learned from experimental myocarditis.

Authors:  A Matsumori
Journal:  Herz       Date:  2012-12       Impact factor: 1.443

6.  Activation of Ca-permeable cation channels by myocarditis-associated antibody in guinea pig ventricular myocytes.

Authors:  M Tominaga; A Matsumori; M Horie; H Yoshida; Y Okada
Journal:  J Clin Invest       Date:  1993-03       Impact factor: 14.808

7.  Alterations in major histocompatibility complex association of myocarditis induced by coxsackievirus B3 mutants selected with monoclonal antibodies to group A streptococci.

Authors:  S A Huber; A Moraska; M Cunningham
Journal:  Proc Natl Acad Sci U S A       Date:  1994-06-07       Impact factor: 11.205

Review 8.  Inflammation, ECG changes and pericardial effusion: whom to biopsy in suspected myocarditis?

Authors:  M Pauschinger; M Noutsias; D Lassner; H-P Schultheiss; U Kuehl
Journal:  Clin Res Cardiol       Date:  2006-08-16       Impact factor: 5.460

9.  An attenuated variant of Coxsackievirus B3 preferentially induces immunoregulatory T cells in vivo.

Authors:  R P Loudon; A F Moraska; S A Huber; P Schwimmbeck; P Schultheiss
Journal:  J Virol       Date:  1991-11       Impact factor: 5.103

10.  Genetic control of Coxsackievirus B3-induced heart-specific autoantibodies associated with chronic myocarditis.

Authors:  M D Traystman; K W Beisel
Journal:  Clin Exp Immunol       Date:  1991-11       Impact factor: 4.330
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