Yumi Yamamoto1, Meindert Danhof1, Elizabeth C M de Lange2. 1. Division of Pharmacology, Cluster Systems Pharmacology, Leiden Academic Centre for Drug Research, Leiden University Gorlaeus Laboratories, Einsteinweg 55, 2333, CC, Leiden, The Netherlands. 2. Division of Pharmacology, Cluster Systems Pharmacology, Leiden Academic Centre for Drug Research, Leiden University Gorlaeus Laboratories, Einsteinweg 55, 2333, CC, Leiden, The Netherlands. ecmdelange@lacdr.leidenuniv.nl.