Annette D de Kloet1, Ulrike M Steckelings2, Colin Sumners3. 1. Department of Physiology and Functional Genomics, College of Medicine, University of Florida, 1600 SW Archer Road, Box 100274, Gainesville, FL, 32610-0274, USA. 2. IMM - Department of Cardiovascular and Renal Research, University of Southern Denmark, Odense, Denmark. 3. Department of Physiology and Functional Genomics, College of Medicine, University of Florida, 1600 SW Archer Road, Box 100274, Gainesville, FL, 32610-0274, USA. csumners@ufl.edu.
Abstract
PURPOSE OF REVIEW: The goal of this review is to assess the evidence that activation of angiotensin type 2 receptors (AT2R) in the brain can lower blood pressure and possibly constitute an endogenous anti-hypertensive mechanism. RECENT FINDINGS: Recent studies that detail the location of AT2R in the brain, particularly within or near cardiovascular control centers, mesh well with findings from pharmacological and gene transfer studies which demonstrate that activation of central AT2R can influence cardiovascular regulation. Collectively, these studies indicate that selective activation of brain AT2R causes moderate decreases in blood pressure in normal animals and more profound anti-hypertensive effects, along with restoration of baroreflex function, in rodent models of neurogenic hypertension. These findings have opened the door to studies that can (i) assess the role of specific AT2R neuron populations in depressing blood pressure, (ii) determine the relevance of such mechanisms, and (iii) investigate interactions between AT2R and depressor angiotensin-(1-7)/Mas mechanisms in the brain.
PURPOSE OF REVIEW: The goal of this review is to assess the evidence that activation of angiotensin type 2 receptors (AT2R) in the brain can lower blood pressure and possibly constitute an endogenous anti-hypertensive mechanism. RECENT FINDINGS: Recent studies that detail the location of AT2R in the brain, particularly within or near cardiovascular control centers, mesh well with findings from pharmacological and gene transfer studies which demonstrate that activation of central AT2R can influence cardiovascular regulation. Collectively, these studies indicate that selective activation of brain AT2R causes moderate decreases in blood pressure in normal animals and more profound anti-hypertensive effects, along with restoration of baroreflex function, in rodent models of neurogenic hypertension. These findings have opened the door to studies that can (i) assess the role of specific AT2R neuron populations in depressing blood pressure, (ii) determine the relevance of such mechanisms, and (iii) investigate interactions between AT2R and depressor angiotensin-(1-7)/Mas mechanisms in the brain.
Authors: Prashant J Ruchaya; Guilherme F Speretta; Graziela Torres Blanch; Hongwei Li; Colin Sumners; José V Menani; Eduardo Colombari; Débora S A Colombari Journal: Neuropeptides Date: 2016-07-20 Impact factor: 3.286
Authors: Annette D de Kloet; Soledad Pitra; Lei Wang; Helmut Hiller; David J Pioquinto; Justin A Smith; Colin Sumners; Javier E Stern; Eric G Krause Journal: Endocrinology Date: 2016-06-06 Impact factor: 4.736
Authors: Lucas A C Souza; Caleb J Worker; Wencheng Li; Fatima Trebak; Trevor Watkins; Ariana Julia B Gayban; Evan Yamasaki; Silvana G Cooper; Bernard T Drumm; Yumei Feng Journal: Am J Physiol Heart Circ Physiol Date: 2019-03-29 Impact factor: 4.733
Authors: Colin Sumners; Amy Alleyne; Vermalí Rodríguez; David J Pioquinto; Jacob A Ludin; Shormista Kar; Zachary Winder; Yuma Ortiz; Meng Liu; Eric G Krause; Annette D de Kloet Journal: Hypertens Res Date: 2019-12-18 Impact factor: 3.872
Authors: Laura Sabatino; Chiara Costagli; Dominga Lapi; Cristina Del Seppia; Giuseppe Federighi; Silvana Balzan; Antonio Colantuoni; Giorgio Iervasi; Rossana Scuri Journal: Front Physiol Date: 2018-11-15 Impact factor: 4.566