Literature DB >> 2848772

Thiourea and dimethylthiourea decrease human neutrophil bactericidal function in vitro.

J H Jackson1, E M Berger, J E Repine.   

Abstract

Addition of thiourea (TU) or dimethylthiourea (DMTU) decreased killing of Staphylococcus aureus, 502A, and decreased concentrations of hydrogen peroxide (H2O2), and hydroxyl radical (.OH), but not superoxide anion (O2-.) or lysozyme concentrations, in mixtures containing human neutrophils in vitro. Addition of TU or DMTU also decreased concentrations of H2O2, .OH, or hypochlorous acid (HOCl) in neutrophil-free mixtures exposed to beta-D-glucose and glucose oxidase, gamma irradiation, or HOCl, respectively. Our results suggest that TU or DMTU can decrease neutrophil-mediated killing of bacteria by inhibiting O2 metabolite-dependent bactericidal mechanisms.

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Year:  1988        PMID： 2848772     DOI： 10.1007/bf00919443

Source DB:  PubMed          Journal:  Inflammation        ISSN： 0360-3997            Impact factor:   4.092


  26 in total

1.  Influence of corticosteroids on human polymorphonuclear leukocyte function in vitro : Reduction of lysosomal enzyme release and superoxide production.

Authors:  I M Goldstein; D Roos; G Weissmann; H B Kaplan
Journal:  Inflammation       Date:  1976-06       Impact factor: 4.092

2.  The peroxidase-thiocyanate-hydrogen peroxide antimicrobial system.

Authors:  S J Klebanoff; W H Clem; R G Luebke
Journal:  Biochim Biophys Acta       Date:  1966-03-28

3.  Acute pulmonary vasoconstriction and thromboxane release during protamine reversal of heparin anticoagulation in awake sheep. Evidence for the role of reactive oxygen metabolites following nonimmunological complement activation.

Authors:  D R Morel; E Lowenstein; T Nguyenduy; D R Robinson; J E Repine; D E Chenoweth; W M Zapol
Journal:  Circ Res       Date:  1988-05       Impact factor: 17.367

4.  H2O2 release from human granulocytes during phagocytosis. I. Documentation, quantitation, and some regulating factors.

Authors:  R K Root; J Metcalf; N Oshino; B Chance
Journal:  J Clin Invest       Date:  1975-05       Impact factor: 14.808

5.  Influence of a deficiency of the second component of complement on the bactericidal activity of neutrophils in vitro.

Authors:  J E Repine; C C Clawson; P S Friend
Journal:  J Clin Invest       Date:  1977-05       Impact factor: 14.808

6.  Thiourea causes endothelial cells in tissue culture to produce neutrophil chemoattractant activity.

Authors:  R F O'Brien; M P Seton; J S Makarski; D M Center; S Rounds
Journal:  Am Rev Respir Dis       Date:  1984-07

7.  Oxygen radical scavengers protect alveolar macrophages from hyperoxic injury in vitro.

Authors:  R N Harada; A E Vatter; J E Repine
Journal:  Am Rev Respir Dis       Date:  1983-10

8.  Oxygen-radical-mediated permeability edema and vasoconstriction in isolated perfused rabbit lungs.

Authors:  R M Tate; K M Vanbenthuysen; D M Shasby; I F McMurtry; J E Repine
Journal:  Am Rev Respir Dis       Date:  1982-11

9.  Augmentation by platelets of granulocyte aggregation in response to chemotaxins: studies utilizing an improved cell preparation technique.

Authors:  H Redl; D E Hammerschmidt; G Schlag
Journal:  Blood       Date:  1983-01       Impact factor: 22.113

10.  Dimethyl sulfoxide prevents DNA nicking mediated by ionizing radiation or iron/hydrogen peroxide-generated hydroxyl radical.

Authors:  J E Repine; O W Pfenninger; D W Talmage; E M Berger; D E Pettijohn
Journal:  Proc Natl Acad Sci U S A       Date:  1981-02       Impact factor: 11.205
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