Literature DB >> 28487220

Variant in a common odorant-binding protein gene is associated with bitter sensitivity in people.

Iole Tomassini Barbarossa1, M Hakan Ozdener2, Latisha Love-Gregory3, Makedonka Mitreva3, Nada A Abumrad3, M Yanina Pepino4.   

Abstract

Deeper understanding of signaling mechanisms underlying bitterness perception in people is essential for designing novel and effective bitter blockers, which could enhance nutrition and compliance with orally administered bitter-tasting drugs. Here we show that variability in a human odorant-binding protein gene, OBPIIa, associates with individual differences in bitterness perception of fat (oleic acid) and of a prototypical bitter stimulus, 6-n-propylthiouracil (PROP), suggesting a novel olfactory role in the modulation of bitterness sensitivity.
Copyright © 2017 Elsevier B.V. All rights reserved.

Entities:  

Keywords:  Bitter taste; Individual differences; Olfaction; Olfactory binding protein; PROP; Smell

Mesh：

Substances：

Year:  2017        PMID： 28487220      PMCID： PMC5534261          DOI： 10.1016/j.bbr.2017.05.015

Source DB:  PubMed          Journal:  Behav Brain Res        ISSN： 0166-4328            Impact factor:   3.332


  17 in total

1.  The Relationship between Chemical Constitution and Taste.

Authors:  A L Fox
Journal:  Proc Natl Acad Sci U S A       Date:  1932-01       Impact factor: 11.205

2.  Mutual action of taste and olfaction.

Authors:  C Murphy; W S Cain; L M Bartoshuk
Journal:  Sens Processes       Date:  1977-05

Review 3.  Bitter taste receptors: Novel insights into the biochemistry and pharmacology.

Authors:  Appalaraju Jaggupilli; Ryan Howard; Jasbir D Upadhyaya; Rajinder P Bhullar; Prashen Chelikani
Journal:  Int J Biochem Cell Biol       Date:  2016-03-16       Impact factor: 5.085

4.  Evidence of an odorant-binding protein in the human olfactory mucus: location, structural characterization, and odorant-binding properties.

Authors:  Loïc Briand; Corinne Eloit; Claude Nespoulous; Valérie Bézirard; Jean-Claude Huet; Céline Henry; Florence Blon; Didier Trotier; Jean-Claude Pernollet
Journal:  Biochemistry       Date:  2002-06-11       Impact factor: 3.162

5.  Multiple routes of chemosensitivity to free fatty acids in humans.

Authors:  Angela Chalé-Rush; John R Burgess; Richard D Mattes
Journal:  Am J Physiol Gastrointest Liver Physiol       Date:  2007-01-18       Impact factor: 4.052

6.  Human olfactory epithelial cells generated in vitro express diverse neuronal characteristics.

Authors:  K E Borgmann-Winter; N E Rawson; H-Y Wang; H Wang; M L Macdonald; M H Ozdener; K K Yee; G Gomez; J Xu; B Bryant; G Adamek; N Mirza; E Pribitkin; C-G Hahn
Journal:  Neuroscience       Date:  2008-10-17       Impact factor: 3.590

7.  Bitter and sweet taste receptors regulate human upper respiratory innate immunity.

Authors:  Robert J Lee; Jennifer M Kofonow; Philip L Rosen; Adam P Siebert; Bei Chen; Laurel Doghramji; Guoxiang Xiong; Nithin D Adappa; James N Palmer; David W Kennedy; James L Kreindler; Robert F Margolskee; Noam A Cohen
Journal:  J Clin Invest       Date:  2014-02-17       Impact factor: 14.808

8.  Dose-Dependent Effects of L-Arginine on PROP Bitterness Intensity and Latency and Characteristics of the Chemical Interaction between PROP and L-Arginine.

Authors:  Melania Melis; Massimiliano Arca; Maria Carla Aragoni; Tiziana Cabras; Claudia Caltagirone; Massimo Castagnola; Roberto Crnjar; Irene Messana; Beverly J Tepper; Iole Tomassini Barbarossa
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9.  Cigarette smoking and obesity are associated with decreased fat perception in women.

Authors:  Marta Yanina Pepino; Julie A Mennella
Journal:  Obesity (Silver Spring)       Date:  2014-01-25       Impact factor: 5.002

10.  The gustin (CA6) gene polymorphism, rs2274333 (A/G), as a mechanistic link between PROP tasting and fungiform taste papilla density and maintenance.

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Journal:  PLoS One       Date:  2013-09-09       Impact factor: 3.240
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  12 in total

1.  Fat Sensation: Fatty Acid Taste and Olfaction Sensitivity and the Link with Disinhibited Eating Behaviour.

Authors:  Sophie Kindleysides; Kathryn L Beck; Daniel C I Walsh; Lisa Henderson; Shakeela N Jayasinghe; Matt Golding; Bernhard H Breier
Journal:  Nutrients       Date:  2017-08-15       Impact factor: 5.717

2.  Effect of chemical interaction between oleic acid and L-Arginine on oral perception, as a function of polymorphisms of CD36 and OBPIIa and genetic ability to taste 6-n-propylthiouracil.

Authors:  Melania Melis; Mariano Mastinu; Massimiliano Arca; Roberto Crnjar; Iole Tomassini Barbarossa
Journal:  PLoS One       Date:  2018-03-22       Impact factor: 3.240

3.  Electrophysiological Responses from the Human Tongue to the Six Taste Qualities and Their Relationships with PROP Taster Status.

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Review 4.  "Smelling and Tasting" Parkinson's Disease: Using Senses to Improve the Knowledge of the Disease.

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Journal:  Front Aging Neurosci       Date:  2020-02-25       Impact factor: 5.750

5.  Changes of Taste, Smell and Eating Behavior in Patients Undergoing Bariatric Surgery: Associations with PROP Phenotypes and Polymorphisms in the Odorant-Binding Protein OBPIIa and CD36 Receptor Genes.

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6.  Olfactory Function in Patients with Inflammatory Bowel Disease (IBD) Is Associated with Their Body Mass Index and Polymorphism in the Odor Binding-Protein (OBPIIa) Gene.

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Review 7.  Molecular and Genetic Factors Involved in Olfactory and Gustatory Deficits and Associations with Microbiota in Parkinson's Disease.

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Review 8.  Factors Influencing the Phenotypic Characterization of the Oral Marker, PROP.

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9.  Odorant binding protein 69a connects social interaction to modulation of social responsiveness in Drosophila.

Authors:  Assa Bentzur; Anat Shmueli; Liora Omesi; Julia Ryvkin; Jon-Michael Knapp; Moshe Parnas; Fred P Davis; Galit Shohat-Ophir
Journal:  PLoS Genet       Date:  2018-04-09       Impact factor: 5.917

10.  TAS2R38 bitter taste receptor and attainment of exceptional longevity.

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