Jorge Isidoro1, Paulo Gil2, Gracinda Costa2, João Pedroso de Lima3, Caseiro Alves4, Nuno C Ferreira5. 1. Medicina Nuclear, Centro Hospitalar e Universitário de Coimbra, Portugal. Electronic address: jisidoro@chuc.min-saude.pt. 2. Medicina Nuclear, Centro Hospitalar e Universitário de Coimbra, Portugal. 3. Medicina Nuclear, Centro Hospitalar e Universitário de Coimbra, Portugal; ICNAS - Instituto de Ciências Nucleares Aplicadas à Saúde, Universidade de Coimbra, Portugal. 4. Imagem Médica, Centro Hospitalar e Universitário de Coimbra, Portugal. 5. ICNAS - Instituto de Ciências Nucleares Aplicadas à Saúde, Universidade de Coimbra, Portugal; Instituto de Biofísica e Biomatemática, Faculdade de Medicina da Universidade de Coimbra, Portugal.
Abstract
PURPOSE: The aim of this study is to compare two routine protocols at our institution, CTPA and V/P-SPECT, in terms of radiation dose to the most exposed organs (lungs and breast) and to the embryo/fetus in the case of pregnant patients. METHODS: At our institution, the CTPA protocol includes a contrast enhanced CT (scan parameters: 100kVp, 700mA, 0.5s/rot, pitch 0.984) and in some cases a non-contrast enhanced CT acquisition (120kVp, 400mA, 0.5s/rot, pitch 1.375). In the V/P-SPECT protocol, ventilation SPECT was performed after inhalation of 99mTc-Technegas, reaching 30MBq in the lungs; perfusion was performed after intravenous administration of 60-120MBq of 99mTc-MAA. The absorbed doses (mGy) to lungs and breast from CTPA were estimated using the "ImPACT CT Patient Dosimetry Calculator". The embryo/fetus dose was estimated for different gestational stages (0-7, 8-12, 13-25 and 26-40weeks) using the web based calculation tool "COnceptus Dose Estimation" (CODE). Doses to organs and embryo/fetus from V/P-SPECT were estimated based on published dose data normalized to administered activity (mGy/MBq). RESULTS: Embryo/fetus absorbed doses are similar for CTPA and V/P-SPECT and bellow 1mGy. The calculated dose to the lungs (breast) was 1.3-10.6 (27-136) times higher from CTPA when compared with V/P-SPECT. CONCLUSION: For the diagnosis of PE in women, if both imaging modalities are available, it is recommended to proceed with V/P-SPECT rather than CTPA due to the considerably lower radiation dose to the breast.
PURPOSE: The aim of this study is to compare two routine protocols at our institution, CTPA and V/P-SPECT, in terms of radiation dose to the most exposed organs (lungs and breast) and to the embryo/fetus in the case of pregnant patients. METHODS: At our institution, the CTPA protocol includes a contrast enhanced CT (scan parameters: 100kVp, 700mA, 0.5s/rot, pitch 0.984) and in some cases a non-contrast enhanced CT acquisition (120kVp, 400mA, 0.5s/rot, pitch 1.375). In the V/P-SPECT protocol, ventilation SPECT was performed after inhalation of 99mTc-Technegas, reaching 30MBq in the lungs; perfusion was performed after intravenous administration of 60-120MBq of 99mTc-MAA. The absorbed doses (mGy) to lungs and breast from CTPA were estimated using the "ImPACT CT Patient Dosimetry Calculator". The embryo/fetus dose was estimated for different gestational stages (0-7, 8-12, 13-25 and 26-40weeks) using the web based calculation tool "COnceptus Dose Estimation" (CODE). Doses to organs and embryo/fetus from V/P-SPECT were estimated based on published dose data normalized to administered activity (mGy/MBq). RESULTS: Embryo/fetus absorbed doses are similar for CTPA and V/P-SPECT and bellow 1mGy. The calculated dose to the lungs (breast) was 1.3-10.6 (27-136) times higher from CTPA when compared with V/P-SPECT. CONCLUSION: For the diagnosis of PE in women, if both imaging modalities are available, it is recommended to proceed with V/P-SPECT rather than CTPA due to the considerably lower radiation dose to the breast.
Authors: Ana Cristina Lopes Albricker; Cláudia Maria Vilas Freire; Simone Nascimento Dos Santos; Monica Luiza de Alcantara; Mohamed Hassan Saleh; Armando Luis Cantisano; José Aldo Ribeiro Teodoro; Carmen Lucia Lascasas Porto; Salomon Israel do Amaral; Orlando Carlos Gloria Veloso; Ana Cláudia Gomes Pereira Petisco; Fanilda Souto Barros; Márcio Vinícius Lins de Barros; Adriano José de Souza; Marcone Lima Sobreira; Robson Barbosa de Miranda; Domingos de Moraes; Carlos Gustavo Yuji Verrastro; Alexandre Dias Mançano; Ronaldo de Souza Leão Lima; Valdair Francisco Muglia; Cristina Sebastião Matushita; Rafael Willain Lopes; Artur Martins Novaes Coutinho; Diego Bromfman Pianta; Alair Augusto Sarmet Moreira Damas Dos Santos; Bruno de Lima Naves; Marcelo Luiz Campos Vieira; Carlos Eduardo Rochitte Journal: Arq Bras Cardiol Date: 2022-04 Impact factor: 2.000
Authors: Cécile Tromeur; Liselotte M van der Pol; Pierre-Yves Le Roux; Yvonne Ende-Verhaar; Pierre-Yves Salaun; Christophe Leroyer; Francis Couturaud; Lucia J M Kroft; Menno V Huisman; Frederikus A Klok Journal: Haematologica Date: 2018-08-16 Impact factor: 9.941
Authors: A Sulieman; O Serhan; H I Al-Mohammed; M Z Mahmoud; M Alkhorayef; B Alonazi; E Manssor; A Yousef Journal: Saudi J Biol Sci Date: 2018-10-04 Impact factor: 4.219