Jing-Jie Wang1, Rong-San Jiang2, Ting-Ting Yen3, Kai-Li Liang4. 1. Department of Otolaryngology, Taichung Veterans General Hospital, Taichung, Taiwan, ROC. 2. Department of Otolaryngology, Taichung Veterans General Hospital, Taichung, Taiwan, ROC; School of Medicine, Chung Shan Medical University, Taichung, Taiwan, ROC; Faculty of Medicine, National Yang-Ming University, Taipei, Taiwan, ROC. 3. Department of Otolaryngology, Taichung Veterans General Hospital, Taichung, Taiwan, ROC; Faculty of Medicine, National Yang-Ming University, Taipei, Taiwan, ROC. 4. Department of Otolaryngology, Taichung Veterans General Hospital, Taichung, Taiwan, ROC; School of Medicine, Chung Shan Medical University, Taichung, Taiwan, ROC; Faculty of Medicine, National Yang-Ming University, Taipei, Taiwan, ROC. Electronic address: kellyliang1107@gmail.com.
Abstract
BACKGROUND: Nasopharyngeal carcinoma (NPC) is a common cancer in eastern Asia. Chemoradiotherapy is the main treatment modality for NPC. Dysphagia and aspiration is not uncommon in post-irradiated NPC patients. The purpose of this study was to investigate the risk factors for recurrent pneumonia and the prognosis. METHODS: A retrospective chart review was conducted from January 2004 to December 2014. NPC patients who had been hospitalized for pneumonia in the study hospital were enrolled. The diagnosis of pneumonia was based on radiological evidence of chest inflammation and clinical symptoms. Patients' characteristics including demographic data, the hospital course, and the outcome of pneumonia were collected and analyzed. RESULTS: A total of 113 NPC patients were enrolled in this study. Among them, 96 NPC patients had pneumonia after radiotherapy: 43 had pneumonia twice, and 18 had multiple episodes of pneumonia. Forty-nine patients had tube feeding. The 30-day mortality rate was 51%. The mortality rate was significantly associated with metastatic nasopharyngeal carcinoma (r = 0.328, p < 0.001). Older age, smoking, body weight loss, and lower cranial nerve (vagus or hypoglossal nerve palsy) were significant predictors of multiple episodes of pneumonia (r2 = 0.687, p = 0.033, 0.034, 0.036, and 0.027, respectively). CONCLUSION: We concluded that old age, smoking, body weight loss, and lower cranial nerve palsies are predisposing factors for multiple episodes of pneumonia in post-irradiated NPC patients. Metastatic cancer status usually leads to a lethal outcome. Early interventions to manage dysphagia in high-risk patients are necessary.
BACKGROUND:Nasopharyngeal carcinoma (NPC) is a common cancer in eastern Asia. Chemoradiotherapy is the main treatment modality for NPC. Dysphagia and aspiration is not uncommon in post-irradiated NPCpatients. The purpose of this study was to investigate the risk factors for recurrent pneumonia and the prognosis. METHODS: A retrospective chart review was conducted from January 2004 to December 2014. NPCpatients who had been hospitalized for pneumonia in the study hospital were enrolled. The diagnosis of pneumonia was based on radiological evidence of chest inflammation and clinical symptoms. Patients' characteristics including demographic data, the hospital course, and the outcome of pneumonia were collected and analyzed. RESULTS: A total of 113 NPCpatients were enrolled in this study. Among them, 96 NPCpatients had pneumonia after radiotherapy: 43 had pneumonia twice, and 18 had multiple episodes of pneumonia. Forty-nine patients had tube feeding. The 30-day mortality rate was 51%. The mortality rate was significantly associated with metastatic nasopharyngeal carcinoma (r = 0.328, p < 0.001). Older age, smoking, body weight loss, and lower cranial nerve (vagus or hypoglossal nerve palsy) were significant predictors of multiple episodes of pneumonia (r2 = 0.687, p = 0.033, 0.034, 0.036, and 0.027, respectively). CONCLUSION: We concluded that old age, smoking, body weight loss, and lower cranial nerve palsies are predisposing factors for multiple episodes of pneumonia in post-irradiated NPCpatients. Metastatic cancer status usually leads to a lethal outcome. Early interventions to manage dysphagia in high-risk patients are necessary.
Authors: Peter K M Ku; Ki Wang; Alexander C Vlantis; Evelyn W K Tang; Thomas S C Hui; Ronald Lai; Zenon W C Yeung; Ryan H W Cho; Thomas Law; Simon Y P Chan; Becky Y T Chan; Jeffrey K T Wong; Andrew van Hasselt; Michael C F Tong Journal: Laryngoscope Investig Otolaryngol Date: 2021-11-27
Authors: Peter K M Ku; Alexander C Vlantis; Thomas S C Hui; David C M Yeung; Alex K F Lee; Thomas Law; Simon Y P Chan; Esther S M Poon; Sophie Y Y Lee; Becky Y T Chan; Twinky Y L Cheung; Laurie Y W Lok; Dennis T H Cheng; Jade W S Li; Ken C W Yam; Christina S M Ho; Kristy P T Fung; Coco S Y Chan; William H S Wang; Jeffrey K T Wong; Victor Abdullah; Andrew van Hasselt; Michael C F Tong Journal: Head Neck Date: 2021-09-15 Impact factor: 3.821