Yon Chul Park1, Jin Kim1, Min Seok Seo2, Sung Won Hong2, Eun Seok Cho1, Jong-Koo Kim1. 1. a Department of Family Medicine , Yonsei University Wonju College of Medicine , Wonju , Korea. 2. b Department of Family Medicine , Gangnam Severance Hospital, Yonsei University College of Medicine , Seoul , Korea.
Abstract
BACKGROUND AND AIMS: Vitamin D deficiency and increased platelet indices are associated with increased rate or risk of several diseases such as cardiovascular disease and metabolic syndrome, respectively. We investigated whether vitamin D deficiency is associated with increased platelet count (PC) and mean platelet volume (MPV). METHODS AND RESULTS: The study included 3190 subjects older than 20 years. Subjects were divided into three groups based on their vitamin D levels: vitamin D deficiency (<10.0 ng/ml); insufficiency (10-20 ng/ml); and sufficiency (>20.0 ng/ml). The associations between platelet indices and various parameters were analyzed by Pearson's correlation analysis and t-tests. Then, multivariate linear regression analyses were done correcting for associated parameters. PC and MPV showed a negative correlation with vitamin D groups by ANOVA and multiple linear regression. PC was inversely related with vitamin D group after adjusting for sex, age, regular exercise, white blood cell count, total cholesterol, hemoglobin, and creatinine levels (β ± SE = -3.461 ± 1.512, P = 0.022). MPV was also inversely related with vitamin D group after adjusting for regular exercise, hemoglobin level, and total cholesterol level (β ± SE = -0.080 ± 0.026, P = 0.002), and this relationship remained statistically significant after adjusting for regular exercise, hemoglobin level, total cholesterol level, diabetes, hypertension, and body mass index (β ± SE=-0.082 ± 0.026, P = 0.002). CONCLUSION: PC and MPV are inversely associated with vitamin D levels in adults.
BACKGROUND AND AIMS: Vitamin D deficiency and increased platelet indices are associated with increased rate or risk of several diseases such as cardiovascular disease and metabolic syndrome, respectively. We investigated whether vitamin D deficiency is associated with increased platelet count (PC) and mean platelet volume (MPV). METHODS AND RESULTS: The study included 3190 subjects older than 20 years. Subjects were divided into three groups based on their vitamin D levels: vitamin D deficiency (<10.0 ng/ml); insufficiency (10-20 ng/ml); and sufficiency (>20.0 ng/ml). The associations between platelet indices and various parameters were analyzed by Pearson's correlation analysis and t-tests. Then, multivariate linear regression analyses were done correcting for associated parameters. PC and MPV showed a negative correlation with vitamin D groups by ANOVA and multiple linear regression. PC was inversely related with vitamin D group after adjusting for sex, age, regular exercise, white blood cell count, total cholesterol, hemoglobin, and creatinine levels (β ± SE = -3.461 ± 1.512, P = 0.022). MPV was also inversely related with vitamin D group after adjusting for regular exercise, hemoglobin level, and total cholesterol level (β ± SE = -0.080 ± 0.026, P = 0.002), and this relationship remained statistically significant after adjusting for regular exercise, hemoglobin level, total cholesterol level, diabetes, hypertension, and body mass index (β ± SE=-0.082 ± 0.026, P = 0.002). CONCLUSION: PC and MPV are inversely associated with vitamin D levels in adults.
Entities:
Keywords:
Mean platelet volumes; platelet count; vitamin D
Authors: Robert W Read; Karen A Schlauch; Gai Elhanan; William J Metcalf; Anthony D Slonim; Ramsey Aweti; Robert Borkowski; Joseph J Grzymski Journal: PLoS One Date: 2019-06-13 Impact factor: 3.240
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