Enantioselective Three-Component Assembly of β'-Aryl Enones Using a Rhodium-Catalyzed Alkyne Hydroacylation/Aryl Boronic Acid Conjugate Addition Sequence.

Rhodium-catalyzed alkyne hydroacylation using alkyl β-S-aldehydes, enantioselective rhodium-catalyzed aryl boronic acid conjugate addition, and sulfide elimination are combined in sequence to provide β'-aryl enones. The reaction sequence is efficient and delivers highly functionalized products with excellent levels of enantiocontrol. Good variation of the three reaction components is demonstrated. The sequence corresponds to the formal regio- and enantioselective monoconjugate addition of aryl boronic acids to dienones.