| Literature DB >> 28485535 |
Wilke C de Vries1, David Grill2, Matthias Tesch1, Andrea Ricker3, Harald Nüsse3, Jürgen Klingauf3, Armido Studer1, Volker Gerke2, Bart Jan Ravoo1.
Abstract
We present the self-assembly of redox-responsive polymer nanocontainers comprising a cyclodextrin vesicle core and a thin reductively cleavable polymer shell anchored via host-guest recognition on the vesicle surface. The nanocontainers are of uniform size, show high stability, and selectively respond to a mild reductive trigger as revealed by dynamic light scattering, transmission electron microscopy, atomic force microscopy, a quantitative thiol assay, and fluorescence spectroscopy. Live cell imaging experiments demonstrate a specific redox-responsive release and cytoplasmic delivery of encapsulated hydrophilic payloads, such as the pH-probe pyranine, and the fungal toxin phalloidin. Our results show the high potential of these stimulus-responsive nanocontainers for cell biological applications requiring a controlled delivery.Entities:
Keywords: controlled release; redox-responsive; self-assembly; supramolecular nanocontainer; vesicles
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Year: 2017 PMID： 28485535 DOI： 10.1002/anie.201702620
Source DB: PubMed Journal: Angew Chem Int Ed Engl ISSN： 1433-7851 Impact factor: 15.336