| Literature DB >> 28485042 |
Luca Ceriani1, Maurizio Martelli2, Annarita Conconi3, Pier L Zinzani4, Andrés J M Ferreri5, Barbara Botto6, Caterina Stelitano7, Manuel Gotti8, Maria G Cabras9, Luigi Rigacci10, Luca Giovanella1, Emanuele Zucca1, Peter W M Johnson11.
Abstract
The International Extranodal Lymphoma Study Group-26 study evaluated the prognostic role of 18-fluorodeoxyglucose positron-emission tomography (PET) in primary mediastinal large B-cell lymphoma. We assessed quantitative PET parameters at diagnosis and post-treatment in 100 patients. The end-of-therapy total lesion glycolysis (TLG) was the best individual outcome predictor, but the combination of baseline TLG and end-of-therapy visual analysis with Deauville Score (DS) showed a better positive predictive value. A model in which baseline TLG is combined with interim DS might identify patients with shorter progression-free survival. PET metrics combined with interim DS may allow early risk assessment and warrants further studies.Entities:
Keywords: positron-emission tomography; positron-emission tomography metrics; primary mediastinal B-cell lymphoma; prognostic factors; total lesion glycolysis
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Year: 2017 PMID: 28485042 DOI: 10.1111/bjh.14728
Source DB: PubMed Journal: Br J Haematol ISSN: 0007-1048 Impact factor: 6.998