Literature DB >> 28484906

The Ethics of Anti-aging Clinical Trials.

Parker Crutchfield1.   

Abstract

Interventions aiming to slow, stop, or reverse the aging process are starting to enter clinical trials. Though this line of research is nascent, it has the potential to not only prevent prolonged human suffering, but also to extend human well-being. As this line of research develops, it is important to understand the ethical constraints of conducting such research. This paper discusses some of these constraints. In particular, it discusses the ethical difficulties of conducting this research in a way that would produce reliable data regarding the effectiveness of an anti-aging intervention. Clinical trials of such interventions, I argue, will be faced with a dilemma between two confounding variables. Eliminating the variables requires introducing ethically problematic research practices. Thus, researchers must either perform research in ethically problematic ways, or forego the conduct of high-impact clinical research on anti-aging interventions.

Entities:  

Keywords:  Health behavior; Informed consent; Research ethics; Study design

Mesh:

Substances:

Year:  2017        PMID: 28484906     DOI: 10.1007/s11948-017-9917-z

Source DB:  PubMed          Journal:  Sci Eng Ethics        ISSN: 1353-3452            Impact factor:   3.525


  7 in total

1.  A meta-analysis of the effectiveness of health belief model variables in predicting behavior.

Authors:  Christopher J Carpenter
Journal:  Health Commun       Date:  2010-12

2.  Long-Term Administration of Nicotinamide Mononucleotide Mitigates Age-Associated Physiological Decline in Mice.

Authors:  Kathryn F Mills; Shohei Yoshida; Liana R Stein; Alessia Grozio; Shunsuke Kubota; Yo Sasaki; Philip Redpath; Marie E Migaud; Rajendra S Apte; Koji Uchida; Jun Yoshino; Shin-Ichiro Imai
Journal:  Cell Metab       Date:  2016-10-27       Impact factor: 27.287

3.  Nicotinamide mononucleotide, a key NAD(+) intermediate, treats the pathophysiology of diet- and age-induced diabetes in mice.

Authors:  Jun Yoshino; Kathryn F Mills; Myeong Jin Yoon; Shin-ichiro Imai
Journal:  Cell Metab       Date:  2011-10-05       Impact factor: 27.287

4.  Social learning theory and the Health Belief Model.

Authors:  I M Rosenstock; V J Strecher; M H Becker
Journal:  Health Educ Q       Date:  1988

5.  Metformin slows down aging and extends life span of female SHR mice.

Authors:  Vladimir N Anisimov; Lev M Berstein; Peter A Egormin; Tatiana S Piskunova; Irina G Popovich; Mark A Zabezhinski; Margarita L Tyndyk; Maria V Yurova; Irina G Kovalenko; Tatiana E Poroshina; Anna V Semenchenko
Journal:  Cell Cycle       Date:  2008-09-11       Impact factor: 4.534

Review 6.  The Health Belief Model: a decade later.

Authors:  N K Janz; M H Becker
Journal:  Health Educ Q       Date:  1984

7.  Metformin improves healthspan and lifespan in mice.

Authors:  Alejandro Martin-Montalvo; Evi M Mercken; Sarah J Mitchell; Hector H Palacios; Patricia L Mote; Morten Scheibye-Knudsen; Ana P Gomes; Theresa M Ward; Robin K Minor; Marie-José Blouin; Matthias Schwab; Michael Pollak; Yongqing Zhang; Yinbing Yu; Kevin G Becker; Vilhelm A Bohr; Donald K Ingram; David A Sinclair; Norman S Wolf; Stephen R Spindler; Michel Bernier; Rafael de Cabo
Journal:  Nat Commun       Date:  2013       Impact factor: 14.919

  7 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.