| Literature DB >> 28482534 |
Mohd Abul Kalam1, Mohammad Raish1, Ajaz Ahmed2, Khalid M Alkharfy2, Kazi Mohsin1, Aws Alshamsan1, Fahad I Al-Jenoobi1, Abdullah M Al-Mohizea1, Faiyaz Shakeel3.
Abstract
Thymoquinone (TQ) is a poorly water soluble bioactive compound which shows poor oral bioavailability upon oral administration. Due to poor aqueous solubility and bioavailability of TQ, various self-nanoemulsifying drug delivery systems (SNEDDS) of TQ were developed and evaluated for enhancement of its hepatoprotective effects and oral bioavailability. Hepatoprotective and pharmacokinetic studies of TQ suspension and TQ-SNEDDS were carried out in rat models. Different SNEDDS formulations of TQ were developed and thermodynamically stable TQ-SNEDDS were characterized for physicochemical parameters and evaluated for drug release studies via dialysis membrane. Optimized SNEDDS formulation of TQ was selected for further evaluation of in vivo evaluation. In vivo hepatoprotective investigations showed significant hepatoprotective effects for optimized TQ-SNEDDS in comparison with TQ suspension. The oral administration of optimized SNEDDS showed significant improvement in in vivo absorption of TQ in comparison with TQ suspension. The relatively bioavailability of TQ was enhanced 3.87-fold by optimized SNEDDS in comparison with TQ suspension. The results of this research work indicated the potential of SNEDDS in enhancing relative bioavailability and therapeutic effects of natural bioactive compounds such as TQ.Entities:
Keywords: Bioavailability; Hepatoprotective effects; Pharmacokinetics; SNEDDS; Thymoquinone
Mesh：
Substances：
Year: 2017 PMID： 28482534 DOI： 10.1016/j.msec.2017.03.088
Source DB: PubMed Journal: Mater Sci Eng C Mater Biol Appl ISSN： 0928-4931 Impact factor: 7.328