| Literature DB >> 28482292 |
Manaf AlMatar1, Husam AlMandeal2, Işıl Var3, Begüm Kayar4, Fatih Köksal4.
Abstract
Tuberculosis presents a grave challenge to health, globally instigating 1.5 million mortalities each year. Following the breakthrough of first-line anti-TB medication, the number of mortalities reduced greatly; nonetheless, the swift appearance of tuberculosis which was drug-resistant, as well as the capability of the bacterium to survive and stay dormant are a considerable problem for public health. In order to address this issue, several novel possible candidates for tuberculosis therapy have been subjected to clinical trials of late. The novel antimycobacterial agents are acquired from different categories of medications, operate through a range of action systems, and are at various phases of advancement. We therefore talk about the present methods of treating tuberculosis and novel anti-TB agents with their action method, in order to advance awareness of these new compounds and medications.Entities:
Keywords: Antibiotic; Antitubercular agents; Clinical trials; Mode of action; Novel drugs; Tuberculosis
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Year: 2017 PMID: 28482292 DOI: 10.1016/j.biopha.2017.04.105
Source DB: PubMed Journal: Biomed Pharmacother ISSN: 0753-3322 Impact factor: 6.529