Literature DB >> 28482292

New drugs for the treatment of Mycobacterium tuberculosis infection.

Manaf AlMatar1, Husam AlMandeal2, Işıl Var3, Begüm Kayar4, Fatih Köksal4.   

Abstract

Tuberculosis presents a grave challenge to health, globally instigating 1.5 million mortalities each year. Following the breakthrough of first-line anti-TB medication, the number of mortalities reduced greatly; nonetheless, the swift appearance of tuberculosis which was drug-resistant, as well as the capability of the bacterium to survive and stay dormant are a considerable problem for public health. In order to address this issue, several novel possible candidates for tuberculosis therapy have been subjected to clinical trials of late. The novel antimycobacterial agents are acquired from different categories of medications, operate through a range of action systems, and are at various phases of advancement. We therefore talk about the present methods of treating tuberculosis and novel anti-TB agents with their action method, in order to advance awareness of these new compounds and medications.
Copyright © 2017 Elsevier Masson SAS. All rights reserved.

Entities:  

Keywords:  Antibiotic; Antitubercular agents; Clinical trials; Mode of action; Novel drugs; Tuberculosis

Mesh:

Substances:

Year:  2017        PMID: 28482292     DOI: 10.1016/j.biopha.2017.04.105

Source DB:  PubMed          Journal:  Biomed Pharmacother        ISSN: 0753-3322            Impact factor:   6.529


  9 in total

1.  Mycobacterial Membrane Proteins QcrB and AtpE: Roles in Energetics, Antibiotic Targets, and Associated Mechanisms of Resistance.

Authors:  Luke Bown; Santosh K Srivastava; Brandon M Piercey; Clarissa K McIsaac; Kapil Tahlan
Journal:  J Membr Biol       Date:  2017-11-02       Impact factor: 1.843

2.  Comprehensive Analysis and Comparison on the Codon Usage Pattern of Whole Mycobacterium tuberculosis Coding Genome from Different Area.

Authors:  Li Gun; Ren Yumiao; Pan Haixian; Zhang Liang
Journal:  Biomed Res Int       Date:  2018-05-08       Impact factor: 3.411

3.  QSAR-Based Virtual Screening: Advances and Applications in Drug Discovery.

Authors:  Bruno J Neves; Rodolpho C Braga; Cleber C Melo-Filho; José Teófilo Moreira-Filho; Eugene N Muratov; Carolina Horta Andrade
Journal:  Front Pharmacol       Date:  2018-11-13       Impact factor: 5.810

Review 4.  Chalcone Derivatives: Promising Starting Points for Drug Design.

Authors:  Marcelo N Gomes; Eugene N Muratov; Maristela Pereira; Josana C Peixoto; Lucimar P Rosseto; Pedro V L Cravo; Carolina H Andrade; Bruno J Neves
Journal:  Molecules       Date:  2017-07-25       Impact factor: 4.411

5.  A New Antisense Phosphoryl Guanidine Oligo-2'-O-Methylribonucleotide Penetrates Into Intracellular Mycobacteria and Suppresses Target Gene Expression.

Authors:  Yulia V Skvortsova; Elena G Salina; Ekaterina A Burakova; Oksana S Bychenko; Dmitry A Stetsenko; Tatyana L Azhikina
Journal:  Front Pharmacol       Date:  2019-09-19       Impact factor: 5.810

6.  Identification of pyrvinium pamoate as an anti-tuberculosis agent in vitro and in vivo by SOSA approach amongst known drugs.

Authors:  Qing Guan; Lingjun Zhan; Zhi-Hao Liu; Qin Pan; Xu-Lin Chen; Zhen Xiao; Chuan Qin; Xiao-Lian Zhang
Journal:  Emerg Microbes Infect       Date:  2020-02-04       Impact factor: 7.163

7.  Acetylene containing 2-(2-hydrazinyl)thiazole derivatives: design, synthesis, and in vitro and in silico evaluation of antimycobacterial activity against Mycobacterium tuberculosis.

Authors:  Lakshmi Haritha Bharathi Maganti; Deepthi Ramesh; Balaji Gowrivel Vijayakumar; Mohd Imran K Khan; Arunkumar Dhayalan; Jayabal Kamalraja; Tharanikkarasu Kannan
Journal:  RSC Adv       Date:  2022-03-21       Impact factor: 3.361

Review 8.  Mycobacterium tuberculosis and Pulmonary Rehabilitation: From Novel Pharmacotherapeutic Approaches to Management of Post-Tuberculosis Sequelae.

Authors:  Andreea-Daniela Meca; Liliana Mititelu-Tarțău; Maria Bogdan; Lorena Anda Dijmarescu; Ana-Maria Pelin; Liliana Georgeta Foia
Journal:  J Pers Med       Date:  2022-04-02

9.  Identification of benzothiazones containing a hexahydropyrrolo[3,4-c]pyrrol moiety as antitubercular agents against MDR-MTB.

Authors:  Xican Ma; Bing Han; Aoyu Wang; Lu Yang; Menghao Huang; Kushan Chowdhury; Jian Gu; Kai Zhang; Kai Lv
Journal:  RSC Adv       Date:  2020-04-07       Impact factor: 4.036

  9 in total

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