Literature DB >> 28482134

Adipocyte-myofibroblast transition as a possible pathophysiological step in androgenetic alopecia.

Ilja L Kruglikov1, Philipp E Scherer2.   

Abstract

Appearance of local fibrotic structures around and beneath hair follicles during their involution is a known hallmark of androgenetic alopecia (AGA). We hypothesise that this fibrosis can be connected with recently uncovered adipocyte-myofibroblast transition (AMT) involving the dermal adipocytes. This reflects that AMT is at least partially androgen-dependent, and we propose that AMT may play a role in AGA.
© 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Entities:  

Keywords:  adipocyte-myofibroblast transition; androgenetic alopecia; perifollicular fibrosis

Mesh：

Substances：

Year:  2017        PMID： 28482134     DOI： 10.1111/exd.13379

Source DB:  PubMed          Journal:  Exp Dermatol        ISSN： 0906-6705            Impact factor:   3.960


  11 in total

Review 1.  The many secret lives of adipocytes: implications for diabetes.

Authors:  Philipp E Scherer
Journal:  Diabetologia       Date:  2018-11-21       Impact factor: 10.122

Review 2.  The Role of Immature and Mature Adipocytes in Hair Cycling.

Authors:  Ilja L Kruglikov; Zhuzhen Zhang; Philipp E Scherer
Journal:  Trends Endocrinol Metab       Date:  2018-12-14       Impact factor: 12.015

Review 3.  Emerging nonmetabolic functions of skin fat.

Authors:  Christian F Guerrero-Juarez; Maksim V Plikus
Journal:  Nat Rev Endocrinol       Date:  2018-01-12       Impact factor: 43.330

Review 4.  Fibroblasts: Origins, definitions, and functions in health and disease.

Authors:  Maksim V Plikus; Xiaojie Wang; Sarthak Sinha; Elvira Forte; Sean M Thompson; Erica L Herzog; Ryan R Driskell; Nadia Rosenthal; Jeff Biernaskie; Valerie Horsley
Journal:  Cell       Date:  2021-07-22       Impact factor: 66.850

Review 5.  Role of adipose tissue in facial aging.

Authors:  Uwe Wollina; Reinhard Wetzker; Mohamed Badawy Abdel-Naser; Ilja L Kruglikov
Journal:  Clin Interv Aging       Date:  2017-12-06       Impact factor: 4.458

6.  General theory of skin reinforcement.

Authors:  Ilja L Kruglikov; Philipp E Scherer
Journal:  PLoS One       Date:  2017-08-10       Impact factor: 3.240

7.  Skin aging as a mechanical phenomenon: The main weak links.

Authors:  Ilja L Kruglikov; Philipp E Scherer
Journal:  Nutr Healthy Aging       Date:  2018-06-15

Review 8.  Adipose Stromal Cell Expansion and Exhaustion: Mechanisms and Consequences.

Authors:  Kristin Eckel-Mahan; Aleix Ribas Latre; Mikhail G Kolonin
Journal:  Cells       Date:  2020-04-02       Impact factor: 6.600

9.  Thermogenic adipocytes: lineage, function and therapeutic potential.

Authors:  Alice E Pollard; David Carling
Journal:  Biochem J       Date:  2020-06-12       Impact factor: 3.857

Review 10.  Adipocytic Progenitor Cells Give Rise to Pathogenic Myofibroblasts: Adipocyte-to-Mesenchymal Transition and Its Emerging Role in Fibrosis in Multiple Organs.

Authors:  Roberta Goncalves Marangoni; Benjamin Korman; John Varga
Journal:  Curr Rheumatol Rep       Date:  2020-09-25       Impact factor: 4.686
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