David G Le Couteur1,2, Devin Wahl3, Sharon L Naismith3. 1. Charles Perkins Centre, University of Sydney, Sydney, Australia. 2. Centre for Education and Research on Ageing and the Ageing and Alzheimers Research Institute, University of Sydney and Concord Hospital, Concord, Australia. 3. Charles Perkins Centre, University of Sydney, Sydney,Australia.