| Literature DB >> 28479340 |
Pedro Henrique Dias Moura Prazeres1, Isadora Fernandes Gilson Sena1, Isabella da Terra Borges1, Patrick Orestes de Azevedo1, Julia Peres Andreotti1, Ana Emília de Paiva1, Viviani Mendes de Almeida1, Daniel Arthur de Paula Guerra1, Gabryella Soares Pinheiro Dos Santos1, Akiva Mintz2, Osvaldo Delbono3, Alexander Birbrair4.
Abstract
Pericytes heterogeneity is based on their morphology, distribution, and markers. It is well known that pericytes from different organs may have distinct embryonic sources. Yamazaki et al. (2017) using several transgenic mouse model reveal by cell-lineage tracing that pericytes are even more heterogeneous than previously appreciated. This study shows that pericytes from within the same tissue may be heterogeneous in their origin. Remarkably, a subpopulation of embryonic dermal pericytes derives from the hematopoietic lineage, an unexpected source. Reconstructing the lineage of pericytes is central to understanding development, and also for the diagnosis and treatment of diseases in which pericytes play important roles.Entities:
Keywords: Embryonic; Origin; Pericytes; Plasticity; Stem cells
Mesh：
Year: 2017 PMID： 28479340 PMCID： PMC6076854 DOI： 10.1016/j.ydbio.2017.05.001
Source DB: PubMed Journal: Dev Biol ISSN： 0012-1606 Impact factor: 3.582