| Literature DB >> 28478910 |
Xuemeng Mi1, Qixin Lou1, Wenjing Fan1, Liqin Zhuang1, You Yang2.
Abstract
A gold(I)-catalyzed glycosylation of Kdo with glycosyl ortho-hexynylbenzoate as donor is reported. The couplings of Kdo ortho-hexynylbenzoate with a set of alcohols promoted by PPh3AuOTf afford Kdo glycosides with good β-selectivities. This glycosylation method allows for the synthesis of β-Kdo monosaccharide with a C5 linker at the reducing end for subsequent conjugation to carrier proteins and arrays.Entities:
Keywords: Glycosyl ortho-hexynylbenzoate; Glycosylation; Gold; Kdo; Synthetic methods
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Year: 2017 PMID： 28478910 DOI： 10.1016/j.carres.2017.04.021
Source DB: PubMed Journal: Carbohydr Res ISSN： 0008-6215 Impact factor: 2.104