Literature DB >> 2847852

Direct evidence for the presence of GABAA receptors on the cytoplasmic side of the Deiters' neurone membrane.

M V Rapallino1, A Cupello, H Hydén.   

Abstract

A newly developed micromethod has been used for studying the rate of passage of 36Cl- ions across single nerve membranes from rabbit Deiters' neurones. The application of gamma-aminobutyric acid (GABA) on the cytoplasmic side of those membranes increases the rate of passage of 36Cl- ions from that side to the other one across the membrane. The maximal effect is exerted by 10(-6) M GABA and it fades at higher neurotransmitter concentrations (10(-5) M to 3.3 x 10(-3) M). The cause of this fading of the effect appears to be a receptor desensitization phenomenon. The 10(-6) M GABA effect is reversed by both 10(-4) M picrotoxin and 10(-5) M bicuculline. The overall pattern of the data indicates the presence of GABAA receptors on the cytoplasmic side of these nerve membranes.

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Year:  1988        PMID： 2847852     DOI： 10.1016/0006-8993(88)90563-x

Source DB:  PubMed          Journal:  Brain Res        ISSN： 0006-8993            Impact factor:   3.252


  7 in total

Review 1.  Unorthodox view of the functioning of a GABAA synapse.

Authors:  Aroldo Cupello; Maria Vittoria Rapallino
Journal:  Cell Mol Neurobiol       Date:  2002-04       Impact factor: 5.046

2.  Can Cl- ions be extruded from a gamma-aminobutyric (GABA)-acceptive nerve cell via GABAA receptors on the plasma membrane cytoplasmic side?

Authors:  A Cupello; A Palm; M V Rapallino; H Hydén
Journal:  Cell Mol Neurobiol       Date:  1991-06       Impact factor: 5.046

3.  Stimulation of chloride in-->out permeation across the Deiters' neuron membrane by pentobarbital on the cytoplasmic side: additional evidence of GABA(A) receptors acting as chloride extrusion pumps.

Authors:  M V Rapallino; H Hydén; A Cupello
Journal:  Neurochem Res       Date:  1999-03       Impact factor: 3.996

4.  Effect of phosphatidylserine on the basal and GABA-activated Cl- permeation across single nerve membranes from rabbit Deiters' neurons.

Authors:  M V Rapallino; A Cupello; P Mainardi; G Besio; C W Loeb
Journal:  Neurochem Res       Date:  1990-06       Impact factor: 3.996

5.  Intracellular GABA-activated in-->out permeation of chloride across the Deiters' neuron membrane: modulation by phosphorylating activities.

Authors:  M V Rapallino; A Cupello; H Hydén
Journal:  Neurochem Res       Date:  1999-08       Impact factor: 3.996

6.  Further evidence for the presence of gamma-aminobutyric acidA (GABAA) receptors on the cytoplasmic side of Deiters' membrane.

Authors:  M V Rapallino; A Cupello; H Hyden
Journal:  Cell Mol Neurobiol       Date:  1992-08       Impact factor: 5.046

7.  The increase in Cl- permeation across the Deiters' neuron membrane by GABA on its cytoplasmic side is abolished by protein kinase C (PKC) activators.

Authors:  M V Rapallino; A Cupello; H Hydén
Journal:  Cell Mol Neurobiol       Date:  1993-10       Impact factor: 5.046
  7 in total

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