Literature DB >> 28477969

Placental stem cells: The promise of curing diseases before birth.

Diana Farmer1.   

Abstract

Regenerative medicine is a rapidly expanding and promising field for many diseases and injuries. Stem cells for regenerative therapies have originally been obtained from bone marrow, but are now readily extracted from a variety of adult tissues. Fetal tissue has recently garnered interest for its ease of differentiation into a variety of phenotypes and its relative abundance of pluripotent-linked transcription factors. However, much ethical concern surrounds the methods of obtaining fetal cells. The placenta has emerged as a potential source of fetal derived cells due to its favorable technical and ethical characteristics, as well as its promising therapeutic properties. This preview focuses on providing on overview on the derivation and characteristics of placental derived stem cells as well as delving into their various clinical applications and potential future directions.
Copyright © 2017 Elsevier Ltd. All rights reserved.

Keywords:  Birth defect; Congenital anomaly; Fetal surgery; In utero transplantation; Mesenchymal stromal cells; Placental stem cell

Mesh:

Year:  2017        PMID: 28477969     DOI: 10.1016/j.placenta.2017.04.022

Source DB:  PubMed          Journal:  Placenta        ISSN: 0143-4004            Impact factor:   3.481


  4 in total

Review 1.  Stem cell manipulation, gene therapy and the risk of cancer stem cell emergence.

Authors:  Flora Clément; Elodie Grockowiak; Florence Zylbersztejn; Gaëlle Fossard; Stéphanie Gobert; Véronique Maguer-Satta
Journal:  Stem Cell Investig       Date:  2017-07-25

2.  Neurodevelopment at Age 10 Years of Children Born <28 Weeks With Fetal Growth Restriction.

Authors:  Steven J Korzeniewski; Elizabeth N Allred; Robert M Joseph; Tim Heeren; Karl C K Kuban; T Michael O'Shea; Alan Leviton
Journal:  Pediatrics       Date:  2017-10-13       Impact factor: 7.124

3.  Impact of Gestational Age on Neuroprotective Function of Placenta-Derived Mesenchymal Stromal Cells.

Authors:  Sarah C Stokes; Sandra K Kabagambe; Chelsey J Lee; Aijun Wang; Diana L Farmer; Priyadarsini Kumar
Journal:  J Surg Res       Date:  2022-01-29       Impact factor: 2.417

4.  Conditioned medium from primary cytotrophoblasts, primary placenta-derived mesenchymal stem cells, or sub-cultured placental tissue promoted HUVEC angiogenesis in vitro.

Authors:  Jun Wei; Yanqiu Yu; Haiying Ma; Shenglu Jiang; Lili Du; Jinfang Liu; Xiaoyan Xu; Xiaomei Lu; Ling Ma; Hua Zhu
Journal:  Stem Cell Res Ther       Date:  2021-02-17       Impact factor: 6.832

  4 in total

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