| Literature DB >> 28477134 |
Romal Stewart1, Gautam Wali2, Chris Perry3, Martin F Lavin4, Francois Féron5,6, Alan Mackay-Sim2, Ratneswary Sutharsan7,8.
Abstract
The molecular pathogenesis of ataxia-telangiectasia (A-T) is not yet fully understood, and a versatile cellular model is required for in vitro studies. The occurrence of continuous neurogenesis and easy access make the multipotent adult stem cells from the olfactory mucosa within the nasal cavity a potential cellular model. We describe an efficient method to establish neuron-like cells from olfactory mucosa biopsies derived from A-T patients for the purpose of studying the cellular and molecular aspects of this debilitating disease.Entities:
Keywords: Ataxia-telangiectasia; Neuronal differentiation; Olfactory mucosa; Stem cells
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Year: 2017 PMID： 28477134 DOI： 10.1007/978-1-4939-6955-5_28
Source DB: PubMed Journal: Methods Mol Biol ISSN： 1064-3745