Literature DB >> 2847711

Potent and selective activity of a new carbocyclic nucleoside analog (carbovir: NSC 614846) against human immunodeficiency virus in vitro.

R Vince1, M Hua, J Brownell, S Daluge, F C Lee, W M Shannon, G C Lavelle, J Qualls, O S Weislow, R Kiser.   

Abstract

Carbocyclic 2',3'-didehydro-2',3'-dideoxyguanosine (Carbovir: NSC 614846), a novel nucleoside analog, emerged as a potent and selective anti-HIV agent from a large screening program conducted by the National Cancer Institute and its contractors. Its hydrolytic stability and its ability to inhibit the infectivity and replication of HIV in T-cells at concentrations of approximately 200- to 400-fold below toxic concentrations make carbovir a top-priority candidate for development as a potential antiretroviral agent in the treatment of AIDS patients.

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Year:  1988        PMID： 2847711     DOI： 10.1016/s0006-291x(88)80950-1

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  27 in total

1.  Activities of the four optical isomers of 2',3'-dideoxy-3'-thiacytidine (BCH-189) against human immunodeficiency virus type 1 in human lymphocytes.

Authors:  R F Schinazi; C K Chu; A Peck; A McMillan; R Mathis; D Cannon; L S Jeong; J W Beach; W B Choi; S Yeola
Journal:  Antimicrob Agents Chemother       Date:  1992-03       Impact factor: 5.191

Review 2.  Mechanisms of nucleoside analog antiviral activity and resistance during human immunodeficiency virus reverse transcription.

Authors:  E J Arts; M A Wainberg
Journal:  Antimicrob Agents Chemother       Date:  1996-03       Impact factor: 5.191

Review 3.  The role of non-P450 enzymes in drug oxidation.

Authors:  C Beedham
Journal:  Pharm World Sci       Date:  1997-12

4.  Evaluation of an antimicrobial soap formula for virucidal efficacy in vitro against human immunodeficiency virus in a blood-virus mixture.

Authors:  G C Lavelle; S L Gubbe; J L Neveaux; B J Bowden
Journal:  Antimicrob Agents Chemother       Date:  1989-12       Impact factor: 5.191

5.  Pharmacokinetics and bioavailability of carbovir, a carbocyclic nucleoside active against human immunodeficiency virus, in rats.

Authors:  Y H Yeom; R P Remmel; S H Huang; M Hua; R Vince; C L Zimmerman
Journal:  Antimicrob Agents Chemother       Date:  1989-02       Impact factor: 5.191

6.  Activities of (-)-carbovir and 3'-azido-3'-deoxythymidine against human immunodeficiency virus in vitro.

Authors:  S G Carter; J A Kessler; C D Rankin
Journal:  Antimicrob Agents Chemother       Date:  1990-06       Impact factor: 5.191

Review 7.  Alpha-carboxynucleoside phosphonates: direct-acting inhibitors of viral DNA polymerases.

Authors:  Jan Balzarini; Alan Ford; Nuala M Maguire; Jubi John; Kalyan Das; Eddy Arnold; Wim Dehaen; Anita Maguire
Journal:  Future Med Chem       Date:  2019-01-16       Impact factor: 3.808

8.  Metabolism of carbovir, a potent inhibitor of human immunodeficiency virus type 1, and its effects on cellular metabolism.

Authors:  W B Parker; S C Shaddix; B J Bowdon; L M Rose; R Vince; W M Shannon; L L Bennett
Journal:  Antimicrob Agents Chemother       Date:  1993-05       Impact factor: 5.191

Review 9.  Metabolism and mechanism of antiretroviral action of purine and pyrimidine derivatives.

Authors:  J Balzarini
Journal:  Pharm World Sci       Date:  1994-04-15

10.  Intestinal absorption of (-)-carbovir in the rat.

Authors:  I Soria; C L Zimmerman
Journal:  Pharm Res       Date:  1994-02       Impact factor: 4.200
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