Phytochemical constituents of fucoidan (Padina tetrastromatica) and its assisted AgNPs for enhanced antibacterial activity.

Biological synthesis of nanomaterials is a growing innovative approach and it was broadly utilised in the field of nanotechnology and nanomedicine. This study illustrates that biosynthesis of silver nanoparticles (AgNPs) using fucoidan extracted from seaweed Padina tetrastromatica. The functional groups of extracted fucoidan were characterised by Fourier transform infrared spectroscopy (FTIR) and used to NPs synthesis. Synthesised AgNPs were characterised by ultraviolet-visible spectra, scanning electron microscope, energy dispersive X-ray, transmission electron microscope, selected area electron diffraction and FTIR. In this study, their main focus is enhancement antibacterial activity of AgNPs coated antibiotics against antibiotic resistant bacteria. Among the microorganisms, Serratia nematodiphila was resistant to novobiocin and penicillin, but it was sensitive to AgNPs impregnated antibiotic discs. The zone of inhibition was 12 and 15 mm. The synergistic effect of combined antibiotics and AgNPs resulted in increased fold area which was greater than the sum of their separate effects. It reveals that AgNPs are highly sought in the medicinal field due to their broad spectrum of antibacterial activity and relatively cheaper. This enhanced synergistic effect potentially superior to control the growth of bacteria and it is the budding process for the development of new remedial agents for severe diseases.