Literature DB >> 28475887

Don't Stop Re-healin'! Cancer as an Ongoing Stem Cell Affair.

Samuel P Rowbotham1, Carla F Kim2.   

Abstract

Tumors have long been suspected of hijacking stem cell mechanisms used for tissue maintenance and repair. Ge et al. now show that skin tumors exhibit merged chromatin profiles from distinct stem cell lineages. This "lineage infidelity" recreates a state akin to transient wound repair that persists to maintain uncontrolled growth.
Copyright © 2017 Elsevier Inc. All rights reserved.

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Year:  2017        PMID： 28475887     DOI： 10.1016/j.cell.2017.04.030

Source DB:  PubMed          Journal:  Cell        ISSN： 0092-8674            Impact factor:   41.582


  2 in total

Review 1.  Into the breach: how cells cope with wounds.

Authors:  Mitsutoshi Nakamura; Andrew N M Dominguez; Jacob R Decker; Alexander J Hull; Jeffrey M Verboon; Susan M Parkhurst
Journal:  Open Biol       Date:  2018-10-03       Impact factor: 6.411

2.  DLG5 suppresses breast cancer stem cell-like characteristics to restore tamoxifen sensitivity by inhibiting TAZ expression.

Authors:  Jie Liu; Juan Li; Pingping Li; Yina Jiang; He Chen; Ruiqi Wang; Fang Cao; Peijun Liu
Journal:  J Cell Mol Med       Date:  2018-11-18       Impact factor: 5.310
  2 in total

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