| Literature DB >> 28475878 |
David S Lorberbaum1, Lori Sussel2.
Abstract
Haploinsufficient GATA6 mutations are associated with human pancreatic agenesis. Shi et al. (2017) in this issue of Cell Stem Cell and Tiyaboonchai et al. (2017) in a recent issue of Cell Reports utilize hPSCs to characterize GATA6 function during human pancreas development. One functional copy of GATA6 is sufficient for definitive endoderm development and pancreas formation, but it is inadequate for functional β cell differentiation.Entities:
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Year: 2017 PMID： 28475878 DOI： 10.1016/j.stem.2017.04.004
Source DB: PubMed Journal: Cell Stem Cell ISSN： 1875-9777 Impact factor: 24.633