Sharon Perlman1,2, Omer Bar-Yosef2,3, Jeffrey-Michael Jacobson2,4, Yinon Gilboa1,2, Estela Derazne2, Reuven Achiron1,2, Eldad Katorza1,2. 1. a Prenatal Diagnostic Unit, Department of Obstetrics and Gynecology , Sheba Medical Center , Ramat Gan , Israel. 2. b Sackler School of Medicine , Tel Aviv University , Tel Aviv , Israel. 3. c Department of Pediatric Neurology , Safra Children's Hospital, Sheba Medical Center , Ramat Gan , Israel. 4. d Department of Diagnostic Imaging , Safra Children's Hospital, Sheba Medical Center , Ramat Gan , Israel.
Abstract
PURPOSE: The aim of our study was to assess the agreement between pre- and post-natal measurements in prenatal isolated ventriculomegaly. METHODS: Ninety-two women were referred for lateral ventricular abnormality and followed prospectively. Cases with at least one dilated lateral ventricle ≥10 mm and a normal work up (serological tests, detailed anatomical scan, fetal brain MR imaging, genetic counseling, and amniocentesis) were considered idiopathic ventriculomegaly and comprised the study group for post-natal follow up. Prenatal measurements were performed by ultrasound and MR imaging. Post-natal measurements were performed by cranial sonography at age of 1-3 months. Measurements were performed in the customary plane for each modality. Paired Student's t test was used to assess the mean difference between pre- and postnatal measurements. RESULTS: Forty three cases comprised the study group for post-natal measurements. A statistically significant decrease in ventricular width (p < .001) was observed between pre- and post-natal measurements. On clinical follow up for 24 months, all cases were normal except three who demonstrated very mild neurological deficits. CONCLUSIONS: Our study indicates statistically significant regression of prenatal isolated ventriculomegaly in the post-natal period.
PURPOSE: The aim of our study was to assess the agreement between pre- and post-natal measurements in prenatal isolated ventriculomegaly. METHODS: Ninety-two women were referred for lateral ventricular abnormality and followed prospectively. Cases with at least one dilated lateral ventricle ≥10 mm and a normal work up (serological tests, detailed anatomical scan, fetal brain MR imaging, genetic counseling, and amniocentesis) were considered idiopathic ventriculomegaly and comprised the study group for post-natal follow up. Prenatal measurements were performed by ultrasound and MR imaging. Post-natal measurements were performed by cranial sonography at age of 1-3 months. Measurements were performed in the customary plane for each modality. Paired Student's t test was used to assess the mean difference between pre- and postnatal measurements. RESULTS: Forty three cases comprised the study group for post-natal measurements. A statistically significant decrease in ventricular width (p < .001) was observed between pre- and post-natal measurements. On clinical follow up for 24 months, all cases were normal except three who demonstrated very mild neurological deficits. CONCLUSIONS: Our study indicates statistically significant regression of prenatal isolated ventriculomegaly in the post-natal period.
Authors: Christina J Ge; Rosa M Polan; Kristin W Baranano; Irina Burd; Ahmet A Baschat; Karin J Blakemore; Edward S Ahn; Eric B Jelin; Angie C Jelin Journal: J Matern Fetal Neonatal Med Date: 2019-10-16