Literature DB >> 28475367

Diglycosidic indole alkaloid derivatives from an aqueous extract of Isatis indigotica roots.

Ling-Jie Meng1, Qing-Lan Guo1, Cheng-Bo Xu1, Cheng-Gen Zhu1, Yu-Feng Liu1, Ming-Hua Chen1, Sheng Lin1, Yu-Huan Li1, Jian-Dong Jiang1, Jian-Gong Shi1.   

Abstract

Six new indole alkaloid diglycosides named isatigotindolediosides A-F (1-6), along with three known analogs (7-9), were isolated from an aqueous extract of the Isatis indigotica roots (ban lan gen). Their structures including the absolute configurations were determined by comprehensive spectroscopic data analysis, combined with enzyme or acid hydrolysis, and comparison of experimental circular dichroism (CD) and calculated electronic circular dichroism (ECD) spectra. In the preliminary assays, compounds 3, 5, and 8 showed antiviral activity against Coxsackie virus B3.

Entities:  

Keywords:  Cruciferae; Isatis indigotica; antiviral activity; indole alkaloid diglycoside; isatigotindolediosides A-F

Mesh：

Substances：

Year:  2017        PMID： 28475367     DOI： 10.1080/10286020.2017.1320547

Source DB:  PubMed          Journal:  J Asian Nat Prod Res        ISSN： 1028-6020            Impact factor:   1.569


  9 in total

1.  A chromosome-scale genome assembly of Isatis indigotica, an important medicinal plant used in traditional Chinese medicine : An Isatis genome.

Authors:  Minghui Kang; Haolin Wu; Qiao Yang; Li Huang; Quanjun Hu; Tao Ma; Zaiyun Li; Jianquan Liu
Journal:  Hortic Res       Date:  2020-02-01       Impact factor: 6.793

2.  C19-Diterpenoid alkaloid arabinosides from an aqueous extract of the lateral root of Aconitum carmichaelii and their analgesic activities.

Authors:  Qinglan Guo; Huan Xia; Xianhua Meng; Gaona Shi; Chengbo Xu; Chenggen Zhu; Tiantai Zhang; Jiangong Shi
Journal:  Acta Pharm Sin B       Date:  2018-03-27       Impact factor: 11.413

3.  Sulfur-enriched alkaloids from the root of Isatis indigotica.

Authors:  Qinglan Guo; Chengbo Xu; Minghua Chen; Sheng Lin; Yuhuan Li; Chenggen Zhu; Jiandong Jiang; Yongchun Yang; Jiangong Shi
Journal:  Acta Pharm Sin B       Date:  2018-08-23       Impact factor: 11.413

4.  Indole alkaloid glycosides with a 1'-(phenyl)ethyl unit from Isatis indigotica leaves.

Authors:  Qinglan Guo; Dawei Li; Chengbo Xu; Chenggen Zhu; Ying Guo; Haibo Yu; Xiaoliang Wang; Jiangong Shi
Journal:  Acta Pharm Sin B       Date:  2019-09-12       Impact factor: 11.413

5.  Discovery, synthesis, and optimization of an N-alkoxy indolylacetamide against HIV-1 carrying NNRTI-resistant mutations from the Isatis indigotica root.

Authors:  Chengbo Xu; Yijing Xin; Minghua Chen; Mingyu Ba; Qinglan Guo; Chenggen Zhu; Ying Guo; Jiangong Shi
Journal:  Eur J Med Chem       Date:  2020-01-22       Impact factor: 6.514

6.  A chromosome-scale genome assembly of Isatis indigotica, an important medicinal plant used in traditional Chinese medicine: An Isatis genome.

Authors:  Minghui Kang; Haolin Wu; Qiao Yang; Li Huang; Quanjun Hu; Tao Ma; Zaiyun Li; Jianquan Liu
Journal:  Hortic Res       Date:  2020-02-01       Impact factor: 6.793

7.  Gastrodin Derivatives from Gastrodia elata.

Authors:  Cheng-Bo Xu; Qing-Lan Guo; Ya-Nan Wang; Sheng Lin; Cheng-Gen Zhu; Jian-Gong Shi
Journal:  Nat Prod Bioprospect       Date:  2019-11-16

8.  8,4'-Oxyneolignane glucosides from an aqueous extract of "ban lan gen" (Isatis indigotica root) and their absolute configurations.

Authors:  Lingjie Meng; Qinglan Guo; Yufeng Liu; Jiangong Shi
Journal:  Acta Pharm Sin B       Date:  2017-10-18       Impact factor: 11.413

9.  Microscopic Mass Spectrometry Imaging Reveals the Distribution of Phytochemicals in the Dried Root of Isatis tinctoria.

Authors:  Li-Xing Nie; Jing Dong; Lie-Yan Huang; Xiu-Yu Qian; Chao-Jie Lian; Shuai Kang; Zhong Dai; Shuang-Cheng Ma
Journal:  Front Pharmacol       Date:  2021-06-29       Impact factor: 5.810
  9 in total

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