Literature DB >> 2847508

The pharmacological effects of allicin, a constituent of garlic oil.

P R Mayeux1, K C Agrawal, J S Tou, B T King, H L Lippton, A L Hyman, P J Kadowitz, D B McNamara.   

Abstract

Garlic has been used in herbal medicine for thousands of years. While garlic oil contains many components and has been widely studied, the pharmacology of pure allicin, a constituent of garlic oil, is not well understood. We report that allicin inhibits human platelet aggregation in vitro without affecting cyclooxygenase or thromboxane synthase activity or cyclic adenosine monophosphate (AMP) levels. Allicin does not alter the activity of vascular prostacyclin synthase. However, it inhibits ionophore A23187-stimulated human neutrophil lysosomal enzyme release. In vivo allicin dilates the mesenteric circulation of the cat independent of prostaglandin release or a beta adrenergic mechanism.

Entities:  

Mesh：

Substances：

Year:  1988        PMID： 2847508     DOI： 10.1007/bf01969110

Source DB:  PubMed          Journal:  Agents Actions        ISSN： 0065-4299


  19 in total

1.  Inhibition of fatty acid oxygenases by onion and garlic oils. Evidence for the mechanism by which these oils inhibit platelet aggregation.

Authors:  J Y Vanderhoek; A N Makheja; J M Bailey
Journal:  Biochem Pharmacol       Date:  1980-12-01       Impact factor: 5.858

2.  Anti-aggregatory actions of calcium channel blockers in cat platelets.

Authors:  G A Schmunk; A M Lefer
Journal:  Res Commun Chem Pathol Pharmacol       Date:  1982-02

3.  Effect of garlic on human platelet aggregation in vitro.

Authors:  A Bordia
Journal:  Atherosclerosis       Date:  1978-08       Impact factor: 5.162

4.  Onion, garlic, and experimental atherosclerosis.

Authors:  G S Sainani; D B Desai; M N Natu; K M Katrodia; V P Valame; P G Sainani
Journal:  Jpn Heart J       Date:  1979-05

5.  Effect of essential oil of onion and garlic on experimental atherosclerosis in rabbits.

Authors:  A Bordia; S K Verma; A K Vyas; B L Khabya; A S Rathore; N Bhu; H K Bedi
Journal:  Atherosclerosis       Date:  1977-03       Impact factor: 5.162

6.  Lack of a causal relationship between the vasodilator effect of papaverine and cyclic AMP production in the dog basilar artery.

Authors:  M Fujioka
Journal:  Br J Pharmacol       Date:  1984-09       Impact factor: 8.739

7.  Influence of verapamil and diltiazem on aggregatory responses in cat and rabbit platelet rich plasma.

Authors:  H L Lippton; P M Horwitz; D B McNamara; A Z Landry; P J Kadowitz
Journal:  Prostaglandins Leukot Med       Date:  1984-10

8.  Cardiovascular actions of prostacyclin (PGI2) in the cat.

Authors:  H L Lippton; P W Paustian; B T Mellion; P K Nelson; L P Feigen; B M Chapnick; A L Hyman; P J Kadowitz
Journal:  Arch Int Pharmacodyn Ther       Date:  1979-09

9.  Interference of the calcium antagonists verapamil and nifedipine with lysosomal enzyme release from rabbit polymorphonuclear leukocytes.

Authors:  J G Elferink
Journal:  Arzneimittelforschung       Date:  1982

10.  Metabolism of prostaglandin endoperoxide by microsomes from cat lung.

Authors:  H S She; D B McNamara; E W Spannhake; A L Hyman; P J Kadowitz
Journal:  Prostaglandins       Date:  1981-04
View more
  6 in total

1.  In vitro inhibition of the growth of Helicobacter pylori by oil-macerated garlic constituents.

Authors:  R Ohta; N Yamada; H Kaneko; K Ishikawa; H Fukuda; T Fujino; A Suzuki
Journal:  Antimicrob Agents Chemother       Date:  1999-07       Impact factor: 5.191

2.  Garlic.

Authors:  P Mansell; J P Reckless
Journal:  BMJ       Date:  1991-08-17

3.  Antiplatelet constituents of garlic and onion.

Authors:  A N Makheja; J M Bailey
Journal:  Agents Actions       Date:  1990-03

4.  Some food toxic for pets.

Authors:  Natália Kovalkovičová; Irena Sutiaková; Juraj Pistl; Václav Sutiak
Journal:  Interdiscip Toxicol       Date:  2009-09-28

5.  Fluorinated Analog NMR s of Organosulfur Compounds from Garlic (Allium sativum): Synthesis, Chemistry and Anti-Angiogenesis and Antithrombotic Studies.

Authors:  Eric Block; Benjamin Bechand; Sivaji Gundala; Abith Vattekkatte; Kai Wang; Shaymaa S Mousa; Kavitha Godugu; Murat Yalcin; Shaker A Mousa
Journal:  Molecules       Date:  2017-11-28       Impact factor: 4.411

6.  Allium sativum L.: the anti-immature leech (Limnatis nilotica) activity compared to Niclosomide.

Authors:  Mahmoud Bahmani; Javad Abbasi; Ava Mohsenzadegan; Sirous Sadeghian; Majid Gholami Ahangaran
Journal:  Comp Clin Path       Date:  2011-12-15
  6 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.