Modulation of Parkinsonian State With Uncertain Disturbance Based on Sliding Mode Control.

Parkinson's disease (PD) is a degenerative disorder of central nervous system that endangers the olds' health seriously. The motor symptoms of PD can be attributed to the distorted relay reliability of thalamus to cortical sensorimotor input that results from the increase of inhibitory input from internal segment of the globus pallidum (GPi). Based on this, we construct the GPi-thalamocortical computational model to generate the normal and pathological firing patterns by varying GPi spike train input. A kind of closed-loop deep brain stimulation (DBS) strategy is proposed here. Our control objective is to make the controlled membrane potential of the thalamic neuron return to the normal firing pattern. The control input that directly acts on the thalamus is the DBS waveform, which is adjusted in real time according to the feedback signal. Aimed at a certain system without the change of object parameters or stochastic disturbance, the input-output feedback linearization method is able to eliminate the error between the system output and the desired output. When uncertain elements taken into consideration in the system, the simulation results indicate that sliding mode control scheme provides better effectiveness and higher robustness.