Burcu Zeydan1, Val J Lowe2, Christopher G Schwarz2, Scott A Przybelski3, Nirubol Tosakulwong3, Samantha M Zuk2, Matthew L Senjem4, Jeffrey L Gunter5, Rosebud O Roberts6, Michelle M Mielke6, Eduardo E Benarroch7, Moses Rodriguez7, Mary M Machulda8, Timothy G Lesnick3, David S Knopman7, Ronald C Petersen7, Clifford R Jack2, Kejal Kantarci2, Orhun H Kantarci7. 1. Department of Neurology, Mayo Clinic College of Medicine, Mayo Clinic and Foundation, Rochester, MN, USA/Department of Radiology, Mayo Clinic College of Medicine, Mayo Clinic and Foundation, Rochester, MN, USA. 2. Department of Radiology, Mayo Clinic College of Medicine, Mayo Clinic and Foundation, Rochester, MN, USA. 3. Department of Health Sciences Research, Mayo Clinic College of Medicine, Mayo Clinic and Foundation, Rochester, MN, USA. 4. Department of Radiology, Mayo Clinic College of Medicine, Mayo Clinic and Foundation, Rochester, MN, USA/Department of Information Technology, Mayo Clinic College of Medicine, Mayo Clinic and Foundation, Rochester, MN, USA. 5. Department of Information Technology, Mayo Clinic College of Medicine, Mayo Clinic and Foundation, Rochester, MN, USA. 6. Department of Neurology, Mayo Clinic College of Medicine, Mayo Clinic and Foundation, Rochester, MN, USA/Department of Health Sciences Research, Mayo Clinic College of Medicine, Mayo Clinic and Foundation, Rochester, MN, USA. 7. Department of Neurology, Mayo Clinic College of Medicine, Mayo Clinic and Foundation, Rochester, MN, USA. 8. Department of Psychiatry and Psychology, Mayo Clinic College of Medicine, Mayo Clinic and Foundation, Rochester, MN, USA.
Abstract
BACKGROUND: There is growing interest in white matter (WM) imaging with positron emission tomography (PET). OBJECTIVES: We studied the association of cognitive function in late multiple sclerosis (MS) with cortical and WM Pittsburgh compound-B PET (PiB-PET) binding. METHODS: In the population-based Mayo Clinic Study of Aging, 24 of 4869 participants had MS (12 underwent PiB-PET). Controls were age and sex matched (5:1). We used automated or semi-automated processing for quantitative image analyses and conditional logistic regression for group differences. RESULTS: MS patients had lower memory ( p = 0.03) and language ( p = 0.02) performance; smaller thalamic volumes ( p = 0.003); and thinner temporal ( p = 0.001) and frontal ( p = 0.045) cortices on magnetic resonance imaging (MRI) than controls. There was no difference in global cortical PiB standardized uptake value ratios between MS and controls ( p = 0.35). PiB uptake was lower in areas of WM hyperintensities compared to normal-appearing white matter (NAWM) in MS ( p = 0.0002). Reduced PiB uptake in both the areas of WM hyperintensities ( r = 0.65; p = 0.02) and NAWM ( r = 0.69; p = 0.01) was associated with decreased visuospatial performance in MS. CONCLUSION: PiB uptake in the cortex in late MS is not different from normal age-matched controls. PiB uptake in the WM in late MS may be a marker of the large network structures' integrity such as those involved in visuospatial performance.
BACKGROUND: There is growing interest in white matter (WM) imaging with positron emission tomography (PET). OBJECTIVES: We studied the association of cognitive function in late multiple sclerosis (MS) with cortical and WM Pittsburgh compound-B PET (PiB-PET) binding. METHODS: In the population-based Mayo Clinic Study of Aging, 24 of 4869 participants had MS (12 underwent PiB-PET). Controls were age and sex matched (5:1). We used automated or semi-automated processing for quantitative image analyses and conditional logistic regression for group differences. RESULTS: MS patients had lower memory ( p = 0.03) and language ( p = 0.02) performance; smaller thalamic volumes ( p = 0.003); and thinner temporal ( p = 0.001) and frontal ( p = 0.045) cortices on magnetic resonance imaging (MRI) than controls. There was no difference in global cortical PiB standardized uptake value ratios between MS and controls ( p = 0.35). PiB uptake was lower in areas of WM hyperintensities compared to normal-appearing white matter (NAWM) in MS ( p = 0.0002). Reduced PiB uptake in both the areas of WM hyperintensities ( r = 0.65; p = 0.02) and NAWM ( r = 0.69; p = 0.01) was associated with decreased visuospatial performance in MS. CONCLUSION:PiB uptake in the cortex in late MS is not different from normal age-matched controls. PiB uptake in the WM in late MS may be a marker of the large network structures' integrity such as those involved in visuospatial performance.
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