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Literature DB >> 2847405

Antiviral and antigenic properties of recombinant porcine interferon gamma.

Abstract

Recombinant porcine interferon gamma (rPoIFN gamma) induced a dose-dependent inhibition of the cytopathic effect produced by vesicular stomatitis virus (VSV) challenge of both homologous and heterologous (bovine) cell lines. In addition, an antiviral effect of rPoIFN gamma was demonstrable against the coronavirus transmissible gastroenteritis virus (TGEV) infection of porcine epithelial cells and of pulmonary macrophages. A rabbit anti-PoIFN gamma antiserum was prepared and shown to specifically neutralize the antiviral effects of natural and recombinant porcine IFN gamma preparations. This antiserum could also neutralize recombinant bovine IFN gamma but not recombinant human IFN gamma. These results suggest antigenic homology of porcine and bovine IFN gamma but antigenic differences between these molecules and human IFN gamma.

Entities: Disease Gene Species

Mesh：

Substances：

Year: 1988 PMID： 2847405 PMCID： PMC7133658 DOI： 10.1016/0165-2427(88)90001-3

Source DB: PubMed Journal: Vet Immunol Immunopathol ISSN： 0165-2427 Impact factor: 2.046

19 in total

1. Augmentation of human polymorphonuclear leukocyte adherence by interferon.

Authors: W K Seow; Y H Thong
Journal: Int Arch Allergy Appl Immunol Date: 1986

2. Two distinct families of human and bovine interferon-alpha genes are coordinately expressed and encode functional polypeptides.

Authors: D J Capon; H M Shepard; D V Goeddel
Journal: Mol Cell Biol Date: 1985-04 Impact factor: 4.272

3. Cloning, sequence, and expression of bovine interferon-gamma.

Authors: D P Cerretti; K McKereghan; A Larsen; D Cosman; S Gillis; P E Baker
Journal: J Immunol Date: 1986-06-15 Impact factor: 5.422

4. High interferon titer in newborn pig intestine during experimentally induced viral enteritis.

Authors: C La Bonnardiere; H Laude
Journal: Infect Immun Date: 1981-04 Impact factor: 3.441

Review 5. On the pathogenesis of transmissible gastroenteritis of swine.

Authors: E O Haelterman
Journal: J Am Vet Med Assoc Date: 1972-02-15 Impact factor: 1.936

6. Alteration of some leukocyte functions following in vivo and in vitro exposure to recombinant bovine alpha- and gamma-interferon.

Authors: H Bielefeldt Ohmann; L A Babiuk
Journal: J Interferon Res Date: 1986-04

7. Production of porcine interleukin-2 and its biological and antigenic relationships with human interleukin-2.

Authors: B Charley; E Petit; C Leclerc; S Stefanos
Journal: Immunol Lett Date: 1985 Impact factor: 3.685

8. In vitro biological activities of Escherichia coli-derived bovine interferons-alpha, -beta, and -gamma.

Authors: C W Czarniecki; E B Hamilton; C W Fennie; R L Wolf
Journal: J Interferon Res Date: 1986-02

9. Replication of transmissible gastroenteritis coronavirus (TGEV) in swine alveolar macrophages.

Authors: H Laude; B Charley; J Gelfi
Journal: J Gen Virol Date: 1984-02 Impact factor: 3.891

10. Potentiation of lymphocyte natural killing by mixtures of alpha or beta interferon with recombinant gamma interferon.

Authors: D A Weigent; M P Langford; W R Fleischmann; G J Stanton
Journal: Infect Immun Date: 1983-04 Impact factor: 3.441

8 in total

1. Failure of antigen-stimulated gammadelta T cells and CD4+ T cells from sensitized cattle to upregulate nitric oxide and mycobactericidal activity of autologous Mycobacterium avium subsp. paratuberculosis-infected macrophages.

Authors: Frank J Simutis; Douglas E Jones; Jesse M Hostetter
Journal: Vet Immunol Immunopathol Date: 2007-01-09 Impact factor: 2.046

Antiviral and antigenic properties of recombinant porcine interferon gamma.

1. Augmentation of human polymorphonuclear leukocyte adherence by interferon.

2. Two distinct families of human and bovine interferon-alpha genes are coordinately expressed and encode functional polypeptides.

3. Cloning, sequence, and expression of bovine interferon-gamma.

4. High interferon titer in newborn pig intestine during experimentally induced viral enteritis.

Review 5. On the pathogenesis of transmissible gastroenteritis of swine.

6. Alteration of some leukocyte functions following in vivo and in vitro exposure to recombinant bovine alpha- and gamma-interferon.

7. Production of porcine interleukin-2 and its biological and antigenic relationships with human interleukin-2.

8. In vitro biological activities of Escherichia coli-derived bovine interferons-alpha, -beta, and -gamma.

9. Replication of transmissible gastroenteritis coronavirus (TGEV) in swine alveolar macrophages.

10. Potentiation of lymphocyte natural killing by mixtures of alpha or beta interferon with recombinant gamma interferon.

1. Failure of antigen-stimulated gammadelta T cells and CD4+ T cells from sensitized cattle to upregulate nitric oxide and mycobactericidal activity of autologous Mycobacterium avium subsp. paratuberculosis-infected macrophages.

2. Organization of two transmissible gastroenteritis coronavirus membrane protein topologies within the virion and core.

3. The induction and characterization of natural porcine interferons alpha and beta.

4. Recombinant porcine interferon-gamma activates in vitro porcine adherent mononuclear cells to produce interleukin 1.

5. Interferon induction in porcine leukocytes with transmissible gastroenteritis virus.

Review 6. Virus infection of polarized epithelial cells.

7. Immunopurification applied to the study of virus protein composition and encapsidation.

8. A missense polymorphism in porcine interferon-gamma cDNA affects antiviral activity of the protein variant.