Literature DB >> 28473667

Reactivating nuclear PTEN to treat CLL.

Rosa Bernardi1, Paolo Ghia1.   

Abstract

Entities:  

Keywords:  PTEN; TP53; USP7; chronic lymohocytic leukemia; small molecule inhibitor

Year:  2017        PMID： 28473667      PMCID： PMC5482590          DOI： 10.18632/oncotarget.17543

Source DB:  PubMed          Journal:  Oncotarget        ISSN： 1949-2553


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  8 in total

1.  A small molecule inhibitor of ubiquitin-specific protease-7 induces apoptosis in multiple myeloma cells and overcomes bortezomib resistance.

Authors:  Dharminder Chauhan; Ze Tian; Benjamin Nicholson; K G Suresh Kumar; Bin Zhou; Ruben Carrasco; Jeffrey L McDermott; Craig A Leach; Mariaterresa Fulcinniti; Matthew P Kodrasov; Joseph Weinstock; William D Kingsbury; Teru Hideshima; Parantu K Shah; Stephane Minvielle; Mikael Altun; Benedikt M Kessler; Robert Orlowski; Paul Richardson; Nikhil Munshi; Kenneth C Anderson
Journal:  Cancer Cell       Date:  2012-09-11       Impact factor: 31.743

Review 2.  The functions and regulation of the PTEN tumour suppressor.

Authors:  Min Sup Song; Leonardo Salmena; Pier Paolo Pandolfi
Journal:  Nat Rev Mol Cell Biol       Date:  2012-04-04       Impact factor: 94.444

Review 3.  Management of chronic lymphocytic leukemia.

Authors:  Paolo Ghia; Michael Hallek
Journal:  Haematologica       Date:  2014-06       Impact factor: 9.941

4.  Reconstitution of PTEN activity by CK2 inhibitors and interference with the PI3-K/Akt cascade counteract the antiapoptotic effect of human stromal cells in chronic lymphocytic leukemia.

Authors:  Medhat Shehata; Susanne Schnabl; Dita Demirtas; Martin Hilgarth; Rainer Hubmann; Elena Ponath; Sigrun Badrnya; Claudia Lehner; Andrea Hoelbl; Markus Duechler; Alexander Gaiger; Christoph Zielinski; Josef D Schwarzmeier; Ulrich Jaeger
Journal:  Blood       Date:  2010-06-24       Impact factor: 22.113

5.  Low expression level of phosphatase and tensin homolog deleted on chromosome ten predicts poor prognosis in chronic lymphocytic leukemia.

Authors:  Zhi-Jian Zou; Run Zhang; Lei Fan; Li Wang; Cheng Fang; Li-Na Zhang; Shu Yang; Yuan-Yuan Li; Jian-Yong Li; Wei Xu
Journal:  Leuk Lymphoma       Date:  2012-10-16

6.  HAUSP is required for p53 destabilization.

Authors:  Jordan M Cummins; Bert Vogelstein
Journal:  Cell Cycle       Date:  2004-06-14       Impact factor: 4.534

7.  miR-26a and miR-214 down-regulate expression of the PTEN gene in chronic lymphocytic leukemia, but not PTEN mutation or promoter methylation.

Authors:  Zhi-Jian Zou; Lei Fan; Li Wang; Ji Xu; Run Zhang; Tian Tian; Jian-Yong Li; Wei Xu
Journal:  Oncotarget       Date:  2015-01-20

8.  Therapeutic inhibition of USP7-PTEN network in chronic lymphocytic leukemia: a strategy to overcome TP53 mutated/deleted clones.

Authors:  Giovanna Carrà; Cristina Panuzzo; Davide Torti; Guido Parvis; Sabrina Crivellaro; Ubaldo Familiari; Marco Volante; Deborah Morena; Marcello Francesco Lingua; Mara Brancaccio; Angelo Guerrasio; Pier Paolo Pandolfi; Giuseppe Saglio; Riccardo Taulli; Alessandro Morotti
Journal:  Oncotarget       Date:  2017-05-30
  8 in total
  2 in total

1.  Ubiquitin-specific protease 7 is a drug-able target that promotes hepatocellular carcinoma and chemoresistance.

Authors:  Wei Zhang; Jingxin Zhang; Chenzhou Xu; Shiqing Zhang; Saiyan Bian; Feng Jiang; Wenkai Ni; Lishuai Qu; Cuihua Lu; Runzhou Ni; Yihui Fan; Mingbing Xiao; Jinxia Liu
Journal:  Cancer Cell Int       Date:  2020-01-28       Impact factor: 5.722

2.  Ubiquitin-specific protease 7 as a potential therapeutic target in dogs with hematopoietic malignancies.

Authors:  Aleksandra Pawlak; Joanna Bajzert; Katarzyna Bugiel; Beatriz Hernández Suárez; Justyna Kutkowska; Andrzej Rapak; Wojciech Hildebrand; Bożena Obmińska-Mrukowicz; Raimundo Freire; Veronique A J Smits
Journal:  J Vet Intern Med       Date:  2021-03-02       Impact factor: 3.333
  2 in total

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