Literature DB >> 28473363

Antacid abuse: a rare cause of severe hypercalcaemia.

Ben Stoney1, Gautam Bagchi1.   

Abstract

We discuss a case of an 81-year-old man who presented to hospital with a case of severe hypercalcaemia (5.07 mmol/L). The two most common causes of hypercalcaemia, making up around 90% of the cases, are malignancy and primary hyperparathyroidism. Initial investigations are guided by this knowledge. In this case, no underlying malignancy or evidence of a parathyroid adenoma causing primary hyperparathyroidism was found. Instead, on further history, it was found that this patient had troublesome dyspepsia symptoms for which he had ingested 10-12 calcium carbonate tablets a day for the preceding 2 years. This amounts to 6.6-7.9 g of calcium carbonate per day compared with the guideline daily intake of calcium of 1 g. His presentation of severe hypercalcaemia was therefore diagnosed as milk-alkali syndrome secondary to calcium carbonate tablet abuse. © BMJ Publishing Group Ltd (unless otherwise stated in the text of the article) 2017. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

Entities:  

Keywords:  Calcium and bone; Drugs: endocrine system; Endocrine system

Mesh:

Substances:

Year:  2017        PMID: 28473363      PMCID: PMC5747649          DOI: 10.1136/bcr-2017-219611

Source DB:  PubMed          Journal:  BMJ Case Rep        ISSN: 1757-790X


  10 in total

1.  Calcium-alkali syndrome in post-surgical hypoparathyroidism.

Authors:  M Fernández-García; L Vázquez; J L Hernández
Journal:  QJM       Date:  2011-09-27

2.  Life-threatening milk-alkali syndrome resulting from antacid ingestion during pregnancy.

Authors:  Michelle V Gordon; Lawrence P McMahon; P Shane Hamblin
Journal:  Med J Aust       Date:  2005-04-04       Impact factor: 7.738

Review 3.  Milk alkali syndrome and the dynamics of calcium homeostasis.

Authors:  Arnold J Felsenfeld; Barton S Levine
Journal:  Clin J Am Soc Nephrol       Date:  2006-04-26       Impact factor: 8.237

4.  Milk alkali syndrome without the milk.

Authors:  Michail Kaklamanos; Petros Perros
Journal:  BMJ       Date:  2007-08-25

Review 5.  The diagnosis and management of hypercalcaemia.

Authors:  Salvatore Minisola; Jessica Pepe; Sara Piemonte; Cristiana Cipriani
Journal:  BMJ       Date:  2015-06-02

6.  Milk alkali syndrome-an unusual syndrome causing an unusual complication.

Authors:  S George; J D Clark
Journal:  Postgrad Med J       Date:  2000-07       Impact factor: 2.401

7.  Got calcium? Welcome to the calcium-alkali syndrome.

Authors:  Ami M Patel; Stanley Goldfarb
Journal:  J Am Soc Nephrol       Date:  2010-04-22       Impact factor: 10.121

8.  Milk-alkali syndrome associated with calcium carbonate consumption. Report of 7 patients with parathyroid hormone levels and an estimate of prevalence among patients hospitalized with hypercalcemia.

Authors:  D P Beall; R H Scofield
Journal:  Medicine (Baltimore)       Date:  1995-03       Impact factor: 1.889

Review 9.  Milk-alkali syndrome.

Authors:  Boris I Medarov
Journal:  Mayo Clin Proc       Date:  2009-03       Impact factor: 7.616

Review 10.  Calcium-alkali syndrome in the modern era.

Authors:  Ami M Patel; Gbemisola A Adeseun; Stanley Goldfarb
Journal:  Nutrients       Date:  2013-11-27       Impact factor: 5.717

  10 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.