| Literature DB >> 28471660 |
Ilaria Monaco1, Simona Camorani2, David Colecchia3, Erica Locatelli1, Pierpaolo Calandro3, Anais Oudin4, Simone Niclou4, Claudio Arra5, Mario Chiariello3, Laura Cerchia2, Mauro Comes Franchini1.
Abstract
Polymeric nanoparticles (PNPs) may efficiently deliver in vivo therapeutics to tumors when conjugated to specific targeting agents. Gint4.T aptamer specifically recognizes platelet-derived growth factor receptor β and can cross the blood-brain barrier (BBB). We synthesized Gint4.T-conjugated PNPs able of high uptake into U87MG glioblastoma (GBM) cells and with astonishing EC50 value (38 pM) when loaded with a PI3K-mTOR inhibitor. We also demonstrated in vivo BBB passage and tumor accumulation in a GBM orthotopic model.Entities:
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Year: 2017 PMID： 28471660 DOI： 10.1021/acs.jmedchem.7b00527
Source DB: PubMed Journal: J Med Chem ISSN： 0022-2623 Impact factor: 7.446