Søren S Olesen1, Jakob L Poulsen1, Asbjørn M Drewes1, Jens B Frøkjær2, Johanna Laukkarinen3, Mikael Parhiala3, Iben Rix4, Srdan Novovic4, Björn Lindkvist5, Louise Bexander5, Georg Dimcevski6, Trond Engjom6, Friedemann Erchinger7, Ingfrid S Haldorsen8, Aldis Pukitis9, Imanta Ozola-Zālīte9, Stephan Haas10, Miroslav Vujasinovic10, J Matthias Löhr10, Antanas Gulbinas11, Nanna M Jensen12, Maiken T Jørgensen13, Camilla Nøjgaard4. 1. a Department of Gastroenterology and Hepatology, Centre for Pancreatic Diseases , Aalborg University Hospital , Denmark. 2. b Department of Radiology , Aalborg University Hospital , Aalborg , Denmark. 3. c Department of Gastroenterology and Alimentary Tract Surgery , Tampere University Hospital , Finland. 4. d Department of Gastroenterology , Hvidovre University Hospital , Copenhagen , Denmark. 5. e Department of Gastroenterology , Gothenborg University Hospital , Sweden. 6. f Department of Gastroenterology , Haukeland University Hospital , Norway. 7. g Department of Medicine , Voss, Haukeland University Hospital , Norway. 8. h Department of Radiology , Haukeland University Hospital , Norway. 9. i Centre of Gastroenterology, Hepatology and Nutrition , Pauls Stradins Clinical University Hospital , Riga , Latvia. 10. j Department of Gastroenterology , Karolinska University Hospital , Stockholm , Sweden. 11. k Department of Surgery , Lithuanian University of Health Sciences , Lithuania. 12. l Department of Gastroenterology , Bispebjerg Hospital , Copenhagen , Denmark. 13. m Department of Gastroenterology , Odense University Hospital , Denmark.
Abstract
OBJECTIVES: Chronic pancreatitis (CP) is a multifaceted disease associated with several risk factors and a complex clinical presentation. We established the Scandinavian Baltic Pancreatic Club (SBPC) Database to characterise and study the natural history of CP in a Northern European cohort. Here, we describe the design of the database and characteristics of the study cohort. METHODS: Nine centres from six different countries in the Scandinavian-Baltic region joined the database. Patients with definitive or probable CP (M-ANNHEIM diagnostic criteria) were included. Standardised case report forms were used to collect several assessment variables including disease aetiology, duration of CP, preceding acute pancreatitis, as well as symptoms, complications, and treatments. The clinical stage of CP was characterised according to M-ANNNHEIM. Yearly follow-up is planned for all patients. RESULTS: The study cohort comprised of 910 patients (608 men: 302 women; median age 58 (IQR: 48-67) years with definite 848 (93%) or probable CP 62 (7%). Nicotine (70%) and alcohol (59%) were the most frequent aetiologies and seen in combination in 44% of patients. A history of recurrent acute pancreatitis was seen in 49% prior to the development of CP. Pain (69%) and exocrine pancreatic insufficiency (68%) were the most common complications followed by diabetes (43%). Most patients (30%) were classified as clinical stage II (symptomatic CP with exocrine or endocrine insufficiency). Less than 10% of the patients had undergone pancreatic surgery. CONCLUSION: The SBPC database provides a mean for future prospective, observational studies of CP in the Northern European continent.
OBJECTIVES:Chronic pancreatitis (CP) is a multifaceted disease associated with several risk factors and a complex clinical presentation. We established the Scandinavian Baltic Pancreatic Club (SBPC) Database to characterise and study the natural history of CP in a Northern European cohort. Here, we describe the design of the database and characteristics of the study cohort. METHODS: Nine centres from six different countries in the Scandinavian-Baltic region joined the database. Patients with definitive or probable CP (M-ANNHEIM diagnostic criteria) were included. Standardised case report forms were used to collect several assessment variables including disease aetiology, duration of CP, preceding acute pancreatitis, as well as symptoms, complications, and treatments. The clinical stage of CP was characterised according to M-ANNNHEIM. Yearly follow-up is planned for all patients. RESULTS: The study cohort comprised of 910 patients (608 men: 302 women; median age 58 (IQR: 48-67) years with definite 848 (93%) or probable CP 62 (7%). Nicotine (70%) and alcohol (59%) were the most frequent aetiologies and seen in combination in 44% of patients. A history of recurrent acute pancreatitis was seen in 49% prior to the development of CP. Pain (69%) and exocrine pancreatic insufficiency (68%) were the most common complications followed by diabetes (43%). Most patients (30%) were classified as clinical stage II (symptomatic CP with exocrine or endocrine insufficiency). Less than 10% of the patients had undergone pancreatic surgery. CONCLUSION: The SBPC database provides a mean for future prospective, observational studies of CP in the Northern European continent.
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