J P Gleeson1, G B Woods2, G A Watson3, J Ryan4, E Doyle5, F Quinn6, J C O'Keane2, J A McCaffrey3. 1. Department of Medical Oncology, Mater Misericordiae University Hospital, Eccles St, Dublin 7, Ireland. jackgleeson@mater.ie. 2. Department of Histopathology, Mater Misericordiae University Hospital, Eccles St, Dublin 7, Ireland. 3. Department of Medical Oncology, Mater Misericordiae University Hospital, Eccles St, Dublin 7, Ireland. 4. Department of Radiology, Mater Misericordiae University Hospital, Eccles St, Dublin 7, Ireland. 5. Central Pathology Laboratory, St. James's Hospital, Dublin 8, Ireland. 6. Histopathology Department, Rotunda Hospital, Parnell Square, Dublin 1, Ireland.
Abstract
BACKGROUND: A 66 years old presented with abnormal postmenopausal vaginal bleeding and was diagnosed with an endometrial lymphoma (diffuse large B cell type, DLBCL). A left breast lesion was found on PET CT which was subsequently biopsy-proven as a separate stage IE DLBCL, but she had no lymph node, bone marrow or spleen involvement. AIMS: This study aimed to review the available literature and discuss the management and staging of synchronous extra-nodal DLBCL's. RESULTS: Our patient was staged as having synchronous stage IE DLBCL's of the endometrium and breast. Subsequent molecular analysis (IgH gene rearrangement analysis) on both lesions, confirmed the two lesions to be clonally unrelated. CONCLUSIONS: Staging of synchronous extra-nodal lymphomas, particularly when they arise in rare sites such as the endometrium and breast, is difficult and previously unreported. We present our rationale for defining our patient's disease as synchronous stage IE DLBCL's.
BACKGROUND: A 66 years old presented with abnormal postmenopausal vaginal bleeding and was diagnosed with an endometrial lymphoma (diffuse large B cell type, DLBCL). A left breast lesion was found on PET CT which was subsequently biopsy-proven as a separate stage IE DLBCL, but she had no lymph node, bone marrow or spleen involvement. AIMS: This study aimed to review the available literature and discuss the management and staging of synchronous extra-nodal DLBCL's. RESULTS: Our patient was staged as having synchronous stage IE DLBCL's of the endometrium and breast. Subsequent molecular analysis (IgH gene rearrangement analysis) on both lesions, confirmed the two lesions to be clonally unrelated. CONCLUSIONS: Staging of synchronous extra-nodal lymphomas, particularly when they arise in rare sites such as the endometrium and breast, is difficult and previously unreported. We present our rationale for defining our patient's disease as synchronous stage IE DLBCL's.
Entities:
Keywords:
Breast lymphoma; DLBCL; Diffuse large B cell lymphoma; Dilemma; Endometrial lymphoma; Non-Hodgkin lymphoma; Staging,; Synchronous
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