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Literature DB >> 28470279

Synthesis of cyclooxygenase metabolites of 8,9-epoxyeicosatrienoic acid (EET): 11- and 15-hydroxy 8,9-EETs.

Bogdan Barnych¹, Amy A Rand, Tomas Cajka, Kin Sing Stephen Lee, Bruce D Hammock.

Abstract

COX metabolites of 8,9-EET, previously observed as potent mitogenic lipid mediators, were synthesized for the first time by using two synthetic approaches. These synthetic materials allow for structural confirmation of COX metabolites of 8,9-EET and further study of their biological roles.

Entities: Chemical Disease Gene Species

Mesh：

Substances：

Year: 2017 PMID： 28470279 PMCID： PMC5527127 DOI： 10.1039/c7ob00789b

Source DB: PubMed Journal: Org Biomol Chem ISSN： 1477-0520 Impact factor: 3.876

30 in total

Review 1. Epoxygenase pathways of arachidonic acid metabolism.

Authors: D C Zeldin
Journal: J Biol Chem Date: 2001-07-12 Impact factor: 5.157

Review 2. EET signaling in cancer.

Authors: Dipak Panigrahy; Emily R Greene; Ambra Pozzi; Dao Wen Wang; Darryl C Zeldin
Journal: Cancer Metastasis Rev Date: 2011-12 Impact factor: 9.264

3. Dual inhibition of cyclooxygenase-2 and soluble epoxide hydrolase synergistically suppresses primary tumor growth and metastasis.

Authors: Guodong Zhang; Dipak Panigrahy; Sung Hee Hwang; Jun Yang; Lisa M Mahakian; Hiromi I Wettersten; Jun-Yan Liu; Yanru Wang; Elizabeth S Ingham; Sarah Tam; Mark W Kieran; Robert H Weiss; Katherine W Ferrara; Bruce D Hammock
Journal: Proc Natl Acad Sci U S A Date: 2014-07-14 Impact factor: 11.205

Review 4. Free radical lipid peroxidation: mechanisms and analysis.

Authors: Huiyong Yin; Libin Xu; Ned A Porter
Journal: Chem Rev Date: 2011-08-23 Impact factor: 60.622

5. Epoxygenase-driven angiogenesis in human lung microvascular endothelial cells.

Authors: Meetha Medhora; John Daniels; Kavita Mundey; Beate Fisslthaler; Rudi Busse; Elizabeth R Jacobs; David R Harder
Journal: Am J Physiol Heart Circ Physiol Date: 2002-09-26 Impact factor: 4.733

6. Lipoxygenase-catalyzed transformation of epoxy fatty acids to hydroxy-endoperoxides: a potential P450 and lipoxygenase interaction.

Authors: Tarvi Teder; William E Boeglin; Alan R Brash
Journal: J Lipid Res Date: 2014-10-07 Impact factor: 5.922

1. Epoxyeicosatrienoic acid (EET)-stimulated angiogenesis is mediated by epoxy hydroxyeicosatrienoic acids (EHETs) formed from COX-2.

Authors: Amy A Rand; Anita Rajamani; Sean D Kodani; Todd R Harris; Lukas Schlatt; Bodgan Barnych; Anthony G Passerini; Bruce D Hammock
Journal: J Lipid Res Date: 2019-10-22 Impact factor: 5.922

1 in total

Synthesis of cyclooxygenase metabolites of 8,9-epoxyeicosatrienoic acid (EET): 11- and 15-hydroxy 8,9-EETs.

Review 1. Epoxygenase pathways of arachidonic acid metabolism.

Review 2. EET signaling in cancer.

3. Dual inhibition of cyclooxygenase-2 and soluble epoxide hydrolase synergistically suppresses primary tumor growth and metastasis.

Review 4. Free radical lipid peroxidation: mechanisms and analysis.

5. Epoxygenase-driven angiogenesis in human lung microvascular endothelial cells.

6. Lipoxygenase-catalyzed transformation of epoxy fatty acids to hydroxy-endoperoxides: a potential P450 and lipoxygenase interaction.

7. Epoxygenase eicosanoids: synthesis of tetrahydrofuran-diol metabolites and their vasoactivity.

8. Cyclooxygenase-derived proangiogenic metabolites of epoxyeicosatrienoic acids.

9. Regiospecific and enantioselective metabolism of 8,9-epoxyeicosatrienoic acid by cyclooxygenase.

10. Human CYP4F3s are the main catalysts in the oxidation of fatty acid epoxides.

1. Epoxyeicosatrienoic acid (EET)-stimulated angiogenesis is mediated by epoxy hydroxyeicosatrienoic acids (EHETs) formed from COX-2.