Literature DB >> 28470278

Development of 19F-NMR chemical shift detection of DNA B-Z equilibrium using 19F-NMR.

S Nakamura1, H Yang1, C Hirata1, F Kersaudy1, K Fujimoto1.   

Abstract

Various DNA conformational changes are in correlation with biological events. In particular, DNA B-Z equilibrium showed a high correlation with translation and transcription. In this study, we developed a DNA probe containing 5-trifluoromethylcytidine or 5-trifluoromethylthymidine to detect DNA B-Z equilibrium using 19F-NMR. Its probe enabled the quantitative detection of B-, Z-, and ss-DNA based on 19F-NMR chemical shift change.

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Year:  2017        PMID： 28470278     DOI： 10.1039/c7ob00706j

Source DB:  PubMed          Journal:  Org Biomol Chem        ISSN： 1477-0520            Impact factor:   3.876


  3 in total

1.  Hydrolysis, polarity, and conformational impact of C-terminal partially fluorinated ethyl esters in peptide models.

Authors:  Vladimir Kubyshkin; Nediljko Budisa
Journal:  Beilstein J Org Chem       Date:  2017-11-16       Impact factor: 2.883

2.  2-Trifluoromethyl-6-mercurianiline Nucleotide, a Sensitive 19F NMR Probe for Hg(II)-mediated Base Pairing.

Authors:  Asmo Aro-Heinilä; Assi Lepistö; Antti Äärelä; Tuomas Antti Lönnberg; Pasi Virta
Journal:  J Org Chem       Date:  2021-12-14       Impact factor: 4.354

3.  5-Fluoro-2'-deoxycytidine as a Probe for the Study of B/Z-DNA Transition by 19F NMR Spectroscopy.

Authors:  Andrei Solodinin; Angeline Gautrais; Samuel Ollivier; Hongbin Yan
Journal:  ACS Omega       Date:  2019-11-15
  3 in total

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