Literature DB >> 28470248

Crystallographic analyses of isoquinoline complexes reveal a new mode of metallo-β-lactamase inhibition.

Guo-Bo Li1, Jürgen Brem, Robert Lesniak, Martine I Abboud, Christopher T Lohans, Ian J Clifton, Sheng-Yong Yang, Juan-Carlos Jiménez-Castellanos, Matthew B Avison, James Spencer, Michael A McDonough, Christopher J Schofield.   

Abstract

Crystallographic analyses of the VIM-5 metallo-β-lactamase (MBL) with isoquinoline inhibitors reveal non zinc ion binding modes. Comparison with other MBL-inhibitor structures directed addition of a zinc-binding thiol enabling identification of potent B1 MBL inhibitors. The inhibitors potentiate meropenem activity against clinical isolates harboring MBLs.

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Year:  2017        PMID： 28470248      PMCID： PMC5516270          DOI： 10.1039/c7cc02394d

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  28 in total

1.  Standard numbering scheme for class B beta-lactamases.

Authors:  M Galleni; J Lamotte-Brasseur; G M Rossolini; J Spencer; O Dideberg; J M Frère
Journal:  Antimicrob Agents Chemother       Date:  2001-03       Impact factor: 5.191

Review 2.  Metallo-beta-lactamases: novel weaponry for antibiotic resistance in bacteria.

Authors:  Michael W Crowder; James Spencer; Alejandro J Vila
Journal:  Acc Chem Res       Date:  2006-10       Impact factor: 22.384

3.  Structural insights into the design of inhibitors for the L1 metallo-beta-lactamase from Stenotrophomonas maltophilia.

Authors:  L Nauton; R Kahn; G Garau; J F Hernandez; O Dideberg
Journal:  J Mol Biol       Date:  2007-10-22       Impact factor: 5.469

Review 4.  Metallo-β-lactamases: a last frontier for β-lactams?

Authors:  Giuseppe Cornaglia; Helen Giamarellou; Gian Maria Rossolini
Journal:  Lancet Infect Dis       Date:  2011-05       Impact factor: 25.071

Review 5.  Updated functional classification of beta-lactamases.

Authors:  Karen Bush; George A Jacoby
Journal:  Antimicrob Agents Chemother       Date:  2009-12-07       Impact factor: 5.191

6.  Competitive inhibitors of the CphA metallo-beta-lactamase from Aeromonas hydrophila.

Authors:  L E Horsfall; G Garau; B M R Liénard; O Dideberg; C J Schofield; J M Frère; M Galleni
Journal:  Antimicrob Agents Chemother       Date:  2007-02-16       Impact factor: 5.191

7.  Structural basis for the broad-spectrum inhibition of metallo-beta-lactamases by thiols.

Authors:  Benoît M R Liénard; Gianpiero Garau; Louise Horsfall; Andreas I Karsisiotis; Christian Damblon; Patricia Lassaux; Cyril Papamicael; Gordon C K Roberts; Moreno Galleni; Otto Dideberg; Jean-Marie Frère; Christopher J Schofield
Journal:  Org Biomol Chem       Date:  2008-05-07       Impact factor: 3.876

Review 8.  Augmentin (amoxicillin/clavulanate) in the treatment of community-acquired respiratory tract infection: a review of the continuing development of an innovative antimicrobial agent.

Authors:  Anthony R White; Clive Kaye; James Poupard; Rienk Pypstra; Gary Woodnutt; Brian Wynne
Journal:  J Antimicrob Chemother       Date:  2004-01       Impact factor: 5.790

Review 9.  Three decades of beta-lactamase inhibitors.

Authors:  Sarah M Drawz; Robert A Bonomo
Journal:  Clin Microbiol Rev       Date:  2010-01       Impact factor: 26.132

Review 10.  Metallo-β-lactamases: structural features, antibiotic recognition, inhibition, and inhibitor design.

Authors:  Jing-Fang Wang; Kuo-Chen Chou
Journal:  Curr Top Med Chem       Date:  2013       Impact factor: 3.295
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  5 in total

1.  Heteroaryl Phosphonates as Noncovalent Inhibitors of Both Serine- and Metallocarbapenemases.

Authors:  Orville A Pemberton; Priyadarshini Jaishankar; Afroza Akhtar; Jessie L Adams; Lindsey N Shaw; Adam R Renslo; Yu Chen
Journal:  J Med Chem       Date:  2019-09-13       Impact factor: 7.446

Review 2.  β-lactam/β-lactamase inhibitor combinations: an update.

Authors:  Kamaleddin H M E Tehrani; Nathaniel I Martin
Journal:  Medchemcomm       Date:  2018-08-17       Impact factor: 3.597

3.  Discovery of [1,2,4]Triazole Derivatives as New Metallo-β-Lactamase Inhibitors.

Authors:  Chen Yuan; Jie Yan; Chen Song; Fan Yang; Chao Li; Cheng Wang; Huiling Su; Wei Chen; Lijiao Wang; Zhouyu Wang; Shan Qian; Lingling Yang
Journal:  Molecules       Date:  2019-12-23       Impact factor: 4.411

4.  N-Aryl mercaptoacetamides as potential multi-target inhibitors of metallo-β-lactamases (MBLs) and the virulence factor LasB from Pseudomonas aeruginosa.

Authors:  Samir Yahiaoui; Katrin Voos; Jörg Haupenthal; Thomas A Wichelhaus; Denia Frank; Lilia Weizel; Marco Rotter; Steffen Brunst; Jan S Kramer; Ewgenij Proschak; Christian Ducho; Anna K H Hirsch
Journal:  RSC Med Chem       Date:  2021-07-29

5.  Discovery of mercaptopropanamide-substituted aryl tetrazoles as new broad-spectrum metallo-β-lactamase inhibitors.

Authors:  Yu-Hang Yan; Jian Chen; Zhen Zhan; Zhu-Jun Yu; Gen Li; Li Guo; Guo-Bo Li; Yong Wu; Yongxiang Zheng
Journal:  RSC Adv       Date:  2020-08-25       Impact factor: 3.361
  5 in total

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