Nicola J Armstrong1,2, Karen A Mather1, Anbupalam Thalamuthu1, Margaret J Wright3,4, Julian N Trollor1,5, David Ames6,7, Henry Brodaty1,8, Peter R Schofield9,10, Perminder S Sachdev1,11, John B Kwok9,10,12. 1. Centre for Healthy Brain Aging, School of Psychiatry, UNSW Australia, Sydney, Australia. 2. Department of Mathematics & Statistics, Murdoch University, Perth, Australia. 3. Queensland Brain Institute, University of Queensland, Brisbane, Australia. 4. Centre for Advanced Imaging, University of Queensland, Brisbane, Australia. 5. Department of Developmental Disability Neuropsychiatry, UNSW Australia, Sydney, Australia. 6. Academic Unit for Psychiatry of Old Age, University of Melbourne, Melbourne, Australia. 7. National Aging Research Institute, Melbourne, Australia. 8. Dementia Collaborative Research Centre - Assessment & Better Care, UNSW Australia, Sydney, Australia. 9. Neuroscience Research Australia, Sydney, Australia. 10. School of Medical Sciences, UNSW Australia, Sydney, Australia. 11. Neuropsychiatric Institute, Prince of Wales Hospital, Randwick, Australia. 12. Brain and Mind Centre - University of Sydney, Camperdown, Australia.
Abstract
AIM: To examine the relationships between two epigenetic clocks, aging and exceptional longevity. MATERIALS & METHODS: Participants were from three adult cohorts with blood DNA methylation data (Illumina 450 K, n = 275, 34-103 years). Epigenetic age (DNAmage) and age acceleration measures were calculated using the Hannum and Horvath epigenetic clocks. RESULTS: Across all cohorts, DNAmage was correlated with chronological age. In the long-lived cohort (Sydney Centenarian Study; 95+, n = 23), DNAmage was lower than chronological age for both clocks. Mean Sydney Centenarian Study Hannum age acceleration was negative, while the converse was observed for the Horvath model. CONCLUSION: Long-lived individuals have a young epigenetic age compared with their chronological age.
AIM: To examine the relationships between two epigenetic clocks, aging and exceptional longevity. MATERIALS & METHODS:Participants were from three adult cohorts with blood DNA methylation data (Illumina 450 K, n = 275, 34-103 years). Epigenetic age (DNAmage) and age acceleration measures were calculated using the Hannum and Horvath epigenetic clocks. RESULTS: Across all cohorts, DNAmage was correlated with chronological age. In the long-lived cohort (Sydney Centenarian Study; 95+, n = 23), DNAmage was lower than chronological age for both clocks. Mean Sydney Centenarian Study Hannum age acceleration was negative, while the converse was observed for the Horvath model. CONCLUSION: Long-lived individuals have a young epigenetic age compared with their chronological age.
Authors: Claudio Franceschi; Paolo Garagnani; Cristina Morsiani; Maria Conte; Aurelia Santoro; Andrea Grignolio; Daniela Monti; Miriam Capri; Stefano Salvioli Journal: Front Med (Lausanne) Date: 2018-03-12
Authors: Jan Bressler; Riccardo E Marioni; Rosie M Walker; Rui Xia; Rebecca F Gottesman; B Gwen Windham; Megan L Grove; Weihua Guan; James S Pankow; Kathryn L Evans; Andrew M Mcintosh; Ian J Deary; Thomas H Mosley; Eric Boerwinkle; Myriam Fornage Journal: J Gerontol A Biol Sci Med Sci Date: 2020-02-14 Impact factor: 6.053